Chinese Academy of Sciences

Dow Global Technolgoies LLC

Qilu Pharmaceutical Co., Ltd.

Shanghai Acebright Pharmaceuticals Co., Ltd.

Yong Gan

Jian Ding

Chunliu Zhu

Zehong Miao

Ao Zhang

Ka Chun A Chan

Qingmin Yang

Shiyan Guo

Li Gao

Sophie Zhai

Xiaoqing Zheng

Li Gan

Xinxin Zhang

Robert I Schmitt

Quanlei Zhu

Disclosed is an SOMCL-9112 solid dispersion. The SOMCL-9112 solid dispersion is characterized by being prepared from the following raw materials in percentage by weight: 5 percent to 60 percent of SOMCL-9112, 5 percent to 90 percent of pharmaceutically acceptable matrix polymer, 0 percent to 20 percent of surfactant, 0 percent to 20 percent of flow aid and 0 percent to 20 percent of plasticizer. Also disclosed are a preparation method of the SOMCL-9112 solid dispersion, a solid medicinal preparation containing the solid dispersion and application of the solid dispersion for preparing a medicine for treating cancer.

SOMCL-9112 solid dispersion and preparation method thereof and SOMCL-9112 solid preparation containing SOMCL-9112 solid dispersion

Sustained release dosage form

A paliperidone double-layered osmotic pump controlled release tablet and the preparation method thereof are disclosed. The double-layered osmotic pump controlled release tablet comprises a rigid membrane, a push layer, a drug layer, an isolation layer and an aesthetic coating, wherein the rigid membrane contains a semi-permeable polymer, a porogen and/or a plasticizer and has one or more drug release orifices on one end, the push layer comprises an expanding material, an osmotic agent, a binder, a colorant and a lubricant, the drug layer contains a pharmaceutically active ingredient, a hydrophilic polymer, an osmotic agent, a colorant, a lubricant and an antistatic agent, the isolation layer is located between the inner surface of the rigid membrane and the push layer, and contains a hydrophilic polymer. The paliperidone double-layered osmotic pump controlled release tablet shows an increasing drug release rate at early stage and keeps a constant drug release rate at later stage.

Paliperidone double-layered osmotic pump controlled release tablet and preparation method thereof

Growing community of inventors

Shanghai, China

Yong Gan