Centre National De La Recherche Scientifique

Essilor International (Compagnie Generale D'optique)

Institut Curie

Societe De Developpement Et De Recherche Industrielle

Essilor International

Urgo Recherche Innovation Et Developpement

Noptrack

Yong Chen

Claudine Biver

Yanjun Liu

Maël Le Berre

Christian Amatore

Matthieu Piel

Laurianne Vagharchakian

Mathilde Reyssat

David Quere

Anne Pepin

Laurent Thouin

Gilles Favre

Fethi Bedioui

Sophie Griveau

Catherine Sella

The subject matter of the present invention is a device for guiding cell migration comprising a substrate having a textured surface intended to be brought into contact with cells, said textured surface having an anisotropic three-dimensional structure consisting of a network of projections inclined relative to the normal to the plane formed by said textured structure, in the direction imparted by said anisotropic structure. The invention also concerns, according to another aspect, a method for guiding cell migration including the bringing into contact of cells with a substrate having a textured surface and an anisotropic three-dimensional structure, said structure consisting of projections inclined as previously described. The device or method according to the invention can in particular be applied in the fields of dermatology, implantology and tissue engineering.

Device for guiding cell migration and guiding method implementing such a device

The invention relates to an article having a nanotextured surface with superhydrophobic properties, comprising an array of vertical tabs, preferably regular, wherein the pillar array fulfils the following conditions: the surface fraction of the pillars &#xd8;is such that 3%&#x2266;&#xd8;&#x2266;13%, preferably 5%&#x2266;&#xd8;&#x2266;12%, preferably 5%&#x2266;&#xd8;&#x2266;13%, even better 5.5%&#x2266;&#xd8;&#x2266;13%, even better 6%&#x2266;&#xd8;&#x2266;13%, and better still 8%&#x2266;&#xd8;&#x2266;13%; the pitch p of the array is such that 100 nm&#x2266;p&#x2266;250 nm; the height h of the pillars is such that 100 nm&#x2266;h&#x2266;400 nm, preferably 250&#x2266;h&#x2266;400 nm, even better 300&#x2266;h&#x2266;400 nm; and the lateral surface of the pillars is inclined at most by an angle of &#xb1;20&#xb0;, preferably &#xb1;10&#xb0; or even better &#xb1;5&#xb0;, in relation to the vertical axis of the pillars.

Article having a nanotextured surface with superhydrophobic properties

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Paris, France

Yong Chen