Liposome Technology, Inc.

Miza Corporation

Yolanda P Quinn

Paul S Uster

Samuel Zalipsky

Shi Kun Huang

Bei Jin

Wei-Ming Zhang

A lipid represented by the formula:wherein each of Rand Ris an alkyl or alkenyl chain having between about 8 to about 24 carbon atoms; n=0&#x2013;20; L is selected from the group consisting of (i) &#x2014;X&#x2014;(C&#x2550;O)&#x2014;Y&#x2014;, (ii) &#x2014;X&#x2014;(C&#x2550;O)&#x2014;, and (iii) &#x2014;X&#x2014;CH&#x2014;, wherein X and Y are independently selected from oxygen, NH, and a direct bond; and Z is a weakly basic moiety that has a pK of less than about 7.4 and greater than about 4.0 is described.

Neutral-cationic lipid for nucleic acid and drug delivery

An aqueous, noncrystalline minoxidil composition for topical use which has significantly improved flux of the drug through human cadaver skin. The composition contains minoxidil complexed with an amphipathic compound, oleic acid and with pharmaceutically acceptable excipients. The composition may be formulated in an aqueous vehicle, or dispersed in fluorochlorocarbon solvent for spray delivery from a self- propelled spray device.

Non-crystalline minoxidil composition

An aqueous, noncrystalline minoxidil composition for topical use. The composition contains minoxidil complexed with an amphipathic compound having a pK less than about 5 and containing a single lipophilic chain moiety and a sulfate, sulfonate, phosphate and phosphonate polar moiety. The composition may be formulated in ointment form, in an aqueous vehicle, or dispersed in a fluorochlorocarbon solvent, for spray delivery from a self-propelled spray device.

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Daly City, CA, United States of America

Yolanda P Quinn