Sandia Corporation

Other

Yolanda Fintschenko

Blake A Simmons

Eric Bryant Cummings

Vincent Hill

Gregory McGraw

Gregory J Fiechtner

Allen Salmi

Microfluidic devices according to embodiments of the present invention include an inlet port, an outlet port, and a channel or chamber having a non-uniform array of insulating features on one or more surfaces. Electrodes are provided for generation of a spatially non-uniform electric field across the array. A voltage source, which may be an A.C. and/or a D.C. voltage source may be coupled to the electrodes for the generation of the electric field.

Dielectrophoresis device and method having nonuniform arrays for manipulating particles

Disclosed is a method for monitoring sources of public water supply for a variety of pathogens by using a combination of ultrafiltration techniques together dielectrophoretic separation techniques. Because water-borne pathogens, whether present due to 'natural' contamination or intentional introduction, would likely be present in drinking water at low concentrations when samples are collected for monitoring or outbreak investigations, an approach is needed to quickly and efficiently concentrate and separate particles such as viruses, bacteria, and parasites in large volumes of water (e.g., 100 L or more) while simultaneously reducing the sample volume to levels sufficient for detecting low concentrations of microbes (e.g., &#x3c;10 mL). The technique is also designed to screen the separated microbes based on specific conductivity and size.

Method for concentration and separation of biological organisms by ultrafiltration and dielectrophoresis

Concentration and separation of biological organisms by ultrafiltration and dielectrophoresis

Disclosed herein are methods and devices for assaying and concentrating analytes in a fluid sample using dielectrophoresis. As disclosed, the methods and devices utilize substrates having a plurality of pores through which analytes can be selectively prevented from passing, or inhibited, on application of an appropriate electric field waveform. The pores of the substrate produce nonuniform electric field having local extrema located near the pores. These nonuniform fields drive dielectrophoresis, which produces the inhibition. Arrangements of electrodes and porous substrates support continuous, bulk, multi-dimensional, and staged selective concentration.

Methods and devices for high-throughput dielectrophoretic concentration

Dielectrophoresis device and method having non-uniform arrays for manipulating particles

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Livermore, CA, United States of America

Yolanda Fintschenko