Sumitomo Dainippon Pharma Co., Ltd.

Minolta Company, Ltd.

Dainippon Sumitomo Pharma Co., Ltd.

Sumitomo Pharma Co., Ltd.

Yoko Takahashi

Hidefumi Yoshinaga

Tomohiro Toyoda

Izumi Sasaki

Itaru Natsutani

Yoshihiro Ichi

Ryu Nagata

Shingo Mizushima

Hiroto Tatamidani

Shoukou Lee

Kantaro Ushiroda

Yoshitaka Isogai

Takashi Munakata

Tomonari Asai

Yuusuke Ikeda

Shinjiro Tsuyumine

The present invention provides a method in which when using (+)-dibenzoyl-D-tartaric acid to optically divide (±)-1-methyl-4-(2,4,6-trimethoxyphenyl)-3-piperidinone, an ether-based solvent is added and an extremely high yield of (R)-1-methyl-4-(2,4,6-trimethoxyphenyl)-3-piperidinone (+)-dibenzoyl-D-tartrate is thereby obtained, a slurry thereof is treated with a base, a 'three-dimensionally bulky reducing agent' is subsequently used, and cis-(−)-flocinopiperidol is thereby produced with surprisingly high selectivity.

Method for producing cis-(-)-flocino piperidol

The present invention relates to a novel serotonin reuptake inhibitor which also exhibits 5-HTantagonistic action (antidepressive and anxiolytic effects), in particular, 5-HTinverse agonistic action comprising Compound (1): 

Pyrazole compound

The present invention relates to a process to prepare a benzimidazole derivative useful as a medicament, an intermediate for preparing the medicament, and a process to prepare the intermediate.

Method for producing benzimidazole derivative

The present invention relates to a novel serotonin reuptake inhibitor which also exhibits 5-HTantagonistic action (antidepressive and anxiolytic effects), in particular, 5-HTinverse agonistic action comprising Compound (1): or a pharmaceutically acceptable salt thereof

The present invention relates to a novel serotonin reuptake inhibitor which also exhibits 5-HTantagonistic action (antidepressive and anxiolytic effects), in particular, 5-HTinverse agonistic action comprising Compound (1): or a pharmaceutically acceptable salt thereofwherein R, R, Rand Rare independently hydrogen or Calkyl etc.; Ris Calkyl or &#x2014;(CRR)-E; R, R, Rand Rare independently hydrogen, fluorine or Calkyl; A is Caryl or heteroaryl etc.; r is 1, 2, 3 or 4; E is Ccycloalkyl or Caryl etc.; L is oxygen, sulfur or &#x2014;NR&#x2014;; n is 1, 2 or 3; Ris hydrogen or Calkyl etc.; and X is hydrogen or halogen etc.

A compound of the following formula (1), or its prodrug or pharmaceutically acceptable salt thereof, being useful as a diabetic medicine or preventive, or blood sugar regulator, or therapeutic agent for hyperlipemia, etc.  wherein the ring Z is an optionally substituted heteroaryl, Wis a single bond, lower alkylene, etc., Aris an optionally substituted aryl, etc., Wis a single bond, lower alkylene, etc., Aris an optionally substituted arylene, etc., each of Wand Wis an optionally substituted lower alkylene, etc., and Ris carboxyl, an alkoxycarbonyl.

Heteroaryl derivatives

Portion of a copying machine with facsimile functions

Printer

Handle and front panel portion of a paper feed cassette

Growing community of inventors

Osaka, Japan

Yoko Takahashi