Eureka Therapeutics, Inc.

Memorial Sloan Kettering Cancer Center

Yoko Nakano

Hong Liu

Yiyang Xu

Javier Morales

Jingyi Xiang

David Spriggs

Vivien Wai-Fan Chan

Pengbo Zhang

Timothy M Acker

Provided herein are compositions, methods, and uses involving anti-Mucin-16 (MUC16) agents that immunospecifically bind an epitope of Mucin-16 (MUC16). Also provided herein are uses and methods for managing, treating, or preventing disorders, such as cancer and diseases associated with positive MUC16 expression.

Antibodies to mucin-16 (MUC16), encoding polynucleotides and methods of treating MUC16-positive cancer

The present application provides constructs comprising an antibody moiety specifically recognizing Glypican 3 (GPC3), such as a cell surface-bound GPC3. Also provided are methods of making and using these constructs.

Constructs specifically recognizing glypican 3 and uses thereof

The present application provides constructs comprising an antibody moiety that specifically binds to a complex comprising a histone H3 peptide and an MHC class I protein. Also provided are methods of making and using these constructs.

Constructs targeting histone H3 peptide/MHC complexes and uses thereof

Growing community of inventors

El Cerrito, CA, United States of America

Yoko Nakano