Dainippon Sumitomo Pharma Co., Ltd.

Sumitomo Chemical Company, Limited

Dainippon Pharmaceutical Company, Limited

Yoko Kan

Shiro Kato

Yoshimi Hirokawa

Hiroshi Yamazaki

Hiroshi Harada

Naoyuki Yoshida

Hiroyuki Nakagawa

Takanori Nakamura

Yukiko Morikage

Kazuo Morikage

Keiji Nakamura

The present invention relates to a bicyclic pyrimidine compound of the following formula (I) or a salt thereof. wherein Ris lower alkyl, cyclic lower alkyl. etc.; Ris H, lower alkyl, lower alkenyl, etc.; Ris H, lower alkyl, lower alkenyl, etc.; X is O, S or &#x2014;N(R)&#x2014;; Ris H or lower alkyl; or Rand Rmay combine each other to form cyclic amino; Y is amido, keto, sulfonyl, etc.; Ris H or lower alkyl; Z is O or S; m and n are 1 or 2. Said compound (I) or a salt thereof have MGAT inhibitory activity, and are useful as an agent for treatment or prophylaxis of adiposity, metabolic syndromes, hyperlipidemia, hyper neutral lipemia, hyper VLDL-mia, hyper fatty acidemia, diabetes mellitus, arteriosclerosis.

Compound having bicyclic pyrimidine structure and pharmaceutical composition comprising the same

Disclosed is a compound having a strong affinity to serotonin-4 receptors, which is useful as an enterokinesis-promoting agent or a digestive tract function-improving agent. Specifically, disclosed is a compound represented by Formula (1) or a pharmaceutically acceptable salt thereof. Also specifically disclosed is a pharmaceutical composition containing a compound represented by Formula (1) or a pharmaceutically acceptable salt thereof. [In Formula (1), Ar represents a group represented by Formula (Ar-1) or Formula (Ar-2).] 

Amide derivative and pharmaceutical composition containing the same

(S)-4-AMINO-5-CHLORO-2-METHOXY-N-&lsqb;1-&lsqb;1-(2-TETRAHYDROFURYL-CARBONYL)-4-PIPERIDINYLMETHYL&rsqb;-4-PIPERIDINYL&rsqb;BENZAMIDE, PROCESS FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME, AND INTERMEDIATE THEREFOR

Growing community of inventors

Osaka, Japan

Yoko Kan