Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai

Japan Science and Technology Agency

Yoko Ikeda

Tomio Takeuchi

Shinichi Kondo

Seiji Shibahara

Shuichi Gomi

Masa Hamada

Daishiro Ikeda

Atsushi Tamura

Hiroo Hoshino

Toshiaki Kudo

Takayuki Usui

Hiroshi Naganawa

Kazuo Umezawa

Masaya Tohyama

Kazunori Imaizumi

Rie Shinei

Taiichi Katayama

Takayuki Manabe

The present invention provides a means for treatment and/or prevention of a disease caused by aberrant splicing, a neurodegenerative disease represented by Alzheimer's disease, or the like. The present invention relates to a nucleic acid which can be associated with generation of a splice variant that lacks exon 5 of presenilin-2 gene, an inhibitor for inhibiting a binding between protein-nucleic acid caused by aberrant splicing, and a method for screening the inhibitor.

Nucleic acid participating in the formation of presenilin-2-gene exon 5-defective splicing variant

As novel substances having an activity of inducing an apoptosis even on the apoptosis-resistant cancer cells, there are obtained polyoxypeptin and deoxypolyoxypeptin represented by the following general formula (I)

Physiologically active polyoxypeptin and deoxypolyoxypeptin and anticancer drugs containing the same

D-.beta.-lysylmethanediamine derivatives and preparation thereof

Pharmaceutical composition for inhibiting the infection with AIDS virus

As new dibekacin derivatives and new arbekacin derivatives are now provided 2'-amino-2'-deoxydibekacin, 2'-amino-5,2'-dideoxydibekacin, 2'-amino-2'-deoxyarbekacin, 2'-amino-5,2'-dideoxyarbekacin, 2'-amino-5,2'-dideoxy-5-epi-fluoroarbekacin and 2'-amino-5,2'-dideoxy-5-epi-aminoarbekacin which all exhibit high antibacterial activity against a wide variety of gram-positive and gram-negative bacteria, including resistant bacteria such as methicillin-resistant Staphylococcus aureus and which are of low toxicity to mammals and are useful as antibacterial agent for treatment of bacterial infections.

Dibekacin derivatives and arbekacin derivatives active against resistant

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Tokyo, Japan

Yoko Ikeda