Shiseido Company, Limited

Yoko Gozu

Shinichiro Haze

Mineyuki Yokoyama

Shoko Yamaguchi

Kenichi Umishio

Katsuyuki Yomogida

Yushi Terajima

Keiko Mori

Atsushi Joichi

Masako Katsuyama

Atsushi Jouichi

The present invention provides a novel substance that promotes expression of filaggrin gene involved in improvement of the moisture retention function of skin. The inventors of the present invention found that expression of filaggrin gene fluctuates rhythmically over a roughly 24 hour cycle, screened candidate substances based on the time at which expression reaches a maximum following addition of the candidate substance, and identified zanthoxylum extract, 3-(1'-piperidine)propionic acid, geranium oil, cypress oil, rose oil, galvanum oil, pepper oil, basil oil, methyl-o-toluate, methyl anthranilate and dimethyl anthranilate as filaggrin gene expression promoting agents.

Filaggrin gene expression promoter

A method for promoting expression of a clock gene and/or a hyaluronic acid synthase gene in skin, comprising applying onto skin a composition comprising one kind or two kinds selected from lavender oil and eucalyptus oil, and an alkylene oxide derivative.

Expression promoting agent for clock gene and hyaluronic acid synthase gene

A natural flavor or fragrance can be easily and effectively produced by using a &ldquo;unicellularized plant&rdquo;, obtained by unicellularizing, without destroying, the cells of a plant usable as a starting material for a natural flavor or fragrance, as a material for the natural flavor or fragrance and further applying an enzymatic treatment or chemical treatment or continuously heating the same, to thereby remarkably shorten the aging period for producing the natural flavor or fragrance, or by homogenizing a plant usable as the starting material quickly after harvesting to thereby promote the aging.

Process of production of natural flavor or fragrance

Growing community of inventors

Yokohama, Japan

Yoko Gozu