The United States of America, as Represented by the Secretary, Department of Health and Human Services

Yoke Peng Loh

Bruce J Baum

Niamh X Cawley

Christopher R Snell

The invention provides a nucleic acid molecule encoding a growth hormone (GH) in which the RSP sorting signal has been mutated, such that the GH can be constitutively secreted by the nonregulated secretory pathway (NRSP) in a mammalian cell. The invention also provides a nucleic acid molecule encoding a GH in which the three-dimensional conformation of the RSP sorting signal has been altered such that the GH can be constitutively secreted by the NRSP in a mammalian cell.

Nucleic acids encoding growth hormone with a modified RSP sorting signal

The invention provides a growth hormone (GH) in which amino acids within the regulated secretory pathway (RSP) sorting signal have been mutated as well as a GH in which the three-dimensional conformation of the RSP sorting signal has been altered, and a composition comprising an effective amount of such a GH in an excipient.

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Bethesda, MD, United States of America

Yoke Peng Loh