Kyowa Hakko Kogyo Co., Ltd.

Other

Yoji Ino

Chikara Murakata

Shiro Akinaga

Nobuyoshi Amishiro

Mayumi Miyata

Yukimasa Shiotsu

Shiro Soga

Harumi Ogawa

Tadakazu Akiyama

Hiroyuki Ishida

Pui-Kai Li

Taisuke Nakata

Takeshi Takahashi

Tsutomu Agatsuma

Kozue Muramatsu

Provided is steroid sulfatase inhibitors comprising, as the active ingredient, an estra-1,3,5(10)-triene derivative which is represented by formula (I):{wherein Rand Rare the same or different and represent a hydrogen atom, a lower alkyl group or, etc.; Rrepresents a hydrogen atom etc.; Rrepresents a hydrogen atom etc.; Rrepresents a hydrogen atom etc.; Rrepresents a cyano group, an amino group, COR(wherein Rrepresents a substituted lower alkyl group etc.), a substituted or unsubstituted aryl group, a substituted or unsubstituted heterocyclic group, etc}, or pharmaceutically acceptable salts thereof.

Estra-1,3,5(10)-triene derivatives

Estra-1,3,5(10),16-tetraene derivatives

Radicicol derivatives

Radioicol derivatives represented by the following formula (I) having tyrosine kinase inhibition activity or pharmacologically acceptable salts thereof:

Estra-1,3,5(10),16-tetraene derivatives represented by the following formula (I):

Radicicol derivatives represented by the following formula (I) having tyrosine kinase inhibition activity or pharmacologically acceptable salts thereof:

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Shizuoka, Japan

Yoji Ino