Ajinomoto Co., Ltd.

Yoichiro Shima

Tamotsu Suzuki

Tatsuya Okuzumi

Tadakiyo Nakagawa

Toshihiko Yoshimura

Masayuki Sugiki

Munetaka Tokumasu

Shinichi Fujita

Misato Noguchi

Shunsuke Kageyama

Youji Yamada

Yoriko Yamamoto

Ayatoshi Andou

Akira Nakayama

Yasuhiro Tanaka

Masahiro Murata

Noriyasu Kataoka

Kazuyuki Sagi

Tatsuhiro Yamada

Koichi Fujita

Itsuya Tanabe

Kenji Shinkai

Hajime Ito

Kaoru Takenaka

Masanao Yoshida

Kazuyuki Ubukata

Takashi Yamamoto

Hideki Matsumoto

Manabu Kitazawa

Naoyuki Fukuchi

Mitsuo Takahashi

Tetsuo Yano

Haruko Hirashima

Akiko Oonuki

Kanna Kuribayashi

Toshihiko Sugiura

Nobuhiko Hayakawa

Agung Eviryanti

Ryohei Yokoyama

Shunsuke Fukuda

Masatsugu Noguchi

Yasuko Nogi

The present invention has searched for a variety of compounds which show IL-12/IL-23 production-inhibitory activities and herein provides a pharmaceutical composition and an agent for preventing or treating IL-12/IL-23 excess production-related diseases, which comprise the compound.

Pyrazolo-pyrimidine compounds

Specific phenylalanine derivatives and analogues thereof have an antagonistic activity to &#x3b1;4 integrin. They are used as therapeutic agents for various diseases concerning &#x3b1;4 integrin.

Phenylalanine derivatives

Amide derivatives represented by the formula (I): wherein:

Amide derivative

The present invention provides a novel compound having a kininogenase-inhibitory action and its pharmaceutical use. The compounds are represented by the formulas (A), (B), (C), (E) and (H): wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof.

Aniline derivatives

The present invention relates to an ether derivative represented by the formula (I), a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof wherein each symbol is as defined in the description, and an ether derivative represented by the formula (III), a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof wherein each symbol is as defined in the description; a pharmaceutical composition containing the ether derivative; and a package containing the pharmaceutical composition and a description of use thereof. A pharmaceutical composition of the present invention, which contains this compound of the present invention has a superior anti-inflammatory and analgesic activity and is useful as various pharmaceutical agents such as an anti-inflammatory agent, an analgesic, a therapeutic agent for inflammatory bowel disease, a therapeutic agent for pollakiuria and/or incontinentia, a therapeutic agent for asthma and the like.

Ether derivative

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Kawasaki, Japan

Yoichiro Shima