Toray Industries, Inc.

Yoichiro Koshi

Reiji Nishio

Yoshinori Kakizawa

Masakazu Koiwa

Nobuo Ida

Joonsik Park

Junji Michizoe

Taisuke Hirano

Jiao Lu

There is provided an immunopotentiator comprising, as an active ingredient, a modified &#x3b2;-glucan which &#x3b2;-glucan and poly(hydroxy acid) are covalently bonded. The immunopotentiator can potently enhance the immunopotentiating effect of &#x3b2;-glucan.

Immunopotentiator

A process of producing an immunogenic particle includes mixing an aqueous solvent A wherein an antigen(s) is/are dissolved and a water-immiscible organic solvent B wherein an amphiphilic polymer(s) whose hydrophobic segment(s) is/are poly(hydroxy acid) is/are dissolved, to form a reversed-phase emulsion; and removing the solvent from the reversed-phase emulsion to obtain an antigen-adjuvant microparticle complex, wherein the aqueous solvent A and/or the water-immiscible organic solvent B contains a surfactant.

Immunogenic composition

A microparticle includes an agglomerate of a hydrophilic active substance containing particle, which particle includes an amphiphilic polymer composed of a hydrophobic segment of poly(hydroxy acid) and a hydrophilic segment of polysaccharides or polyethylene glycol, and a hydrophilic active substance. It is characterized by an efficient inclusion of the hydrophilic active substance, and a release of the hydrophilic active substance at an appropriate speed in the human body, and is hence very useful as a DDS pharmaceutical preparation.

Microparticle and pharmaceutical composition thereof

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Kamakura, Japan

Yoichiro Koshi