Daicel Chemical Industries, Ltd.

Yoichi Yuki

Masaki Hasegawa

Kazuhiko Saigo

Kouzou Tachibana

Tohru Shibata

Ichiro Okamoto

Hiroyuki Nakamura

Ryoji Noyori

Akito Ichida

Masahiko Hayashi

A carboalkylated amino alcohol having each of the below shown formulae is novel and optically active. A separating agent comprising the alcohol and a support is effectively useful to separate a variety of racemates for example with chromatography. The alcohol may be chemically or physically combined with the support. ##STR1## [wherein Ph represents a phenyl group, R represents a hydrogen atom, an alkyl group having the carbon number of 1 to 10, or an aryl group having the carbon number of 6 to 10, X represents an --O-- group or a --S-- group, and Z represents a hydrogen atom, an alkyl group having the carbon number of 1 to 10 or a metal element]

Optically active carboalkylated amino alcohols and their utilization in

A carboalkylated amino alcohol having each of the below shown formulae is novel and optically active. A separating agent comprising the alcohol and a support is effectively useful to separate a variety of racemates for example with chromatography. The alcohol may be chemically or physically combined with the support. ##STR1## [wherein Ph represents a phenyl group, R represents a hydrogen atom, an alkyl group having the carbon number of 1 to 10, or an aryl group having the carbon number of 6 to 10, X represents an --O-- group or a --S-- group, and Z represents a hydrogen atom, an alkyl group having the carbon number of 1 to 10 or a metal element].

A carboalkylated amino alcohol having each of the below shown formulae is novel and optically active. A separating agent comprising the alcohol and a support is effectively useful to separate a variety of racemates for example with chromatography. The alcohol may be chemically or physically combined with the support. ##STR1## [wherein Ph represents a phenyl group, R represents a hydrogen atom, an alkyl group having the carbon number of 1 to 10, or an aryl group having the carbon number of 6 to 10, X represents an --0-- group or a --S-- group, and Z represents a hydrogen atom, an alkyl group having the carbon number of 1 to 10 or a metal element].

Disclosed is an agent for resolving a mixture of optical isomers which includes cellulose triacetate of the type II form combined with a carrier as a resolving agent, to separate said isomers from each other and means for performing chromatographic elution.

Resolving agent

Disclosed is a method for resolving a mixture of optical isomers which comprises contacting said mixture with a cellulose triacetate consisting essential of the type II form, as a resolving agent, to separate said isomers from each other.

A triarylmethyl methacrylate is produced by reacting methacrylic acid with a triarylmethylating agent in an inert, organic solvent containing therein an excess amount of an amine or in the presence of an anion exchanger.

Process for preparing triarylmethyl methacrylate

A racemic mixture can be optically resolved by liquid chromatography, using a packing of the compound: ##STR1## wherein at least one group selected from among Y.sup.1, Y.sup.2 and Y.sup.3 represents silica gel and/or a siloxane bond moiety therewith and others represent each a hydrogen atom, an alkyl group having one to 20 carbon atoms, an aryl group having six to 20 carbon atoms, an arylalkyl group having seven to 20 carbon atoms, a halogen atom, a hydroxyl group, an alkoxy group having one to 20 carbon atoms or a combination thereof; X represents a spacer having one to 20 carbon atoms; and R represents a metallic slat of optically active t-leucine or tryptophane.

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Himeji, Japan

Yoichi Yuki