Mitsubishi Tanabe Pharma Corporation

Shanghai Pharmaceuticals Holding Co., Ltd.

Sharp Kabushiki Kaisha Corporation

Yoichi Takahashi

Takayuki Kawaguchi

Toru Iijima

Hidenori Akatsuka

Nobumasa Awai

Jingkang Shen

Guangxin Xia

Hiroshi Sugama

Kazuhiko Ishikawa

Jianshu Xie

Huixin Wan

Miki Hirai

Yuko Togashi

Toru Iljima

The present invention provides a nitrogen-containing saturated heterocyclic compound of the formula [I] which is useful as a renin inhibitor. wherein Ris a cycloalkyl group or an alkyl,

Renin inhibitor

The present invention provides a morpholine derivative of the formula [I]; wherein Ris a substituted alkyl group, an optionally substituted aryl group, an optionally substituted heterocyclo group, a cycloalkyl group or an alkyl group; Ris a substituted alkyl group, an optionally substituted aryl group, an optionally substituted heterocyclo group, an optionally substituted alkylcarbonyl group, an optionally substituted arylcarbonyl group, an optionally substituted heterocyclo-substituted carbonyl group or a cycloalkylcarbonyl group; T is a methylene group or a carbonyl group; R, R, Rand Rare the same or different and a hydrogen atom, an optionally substituted carbamoyl group or an optionally substituted alkyl group;or pharmaceutically acceptable salts thereof. These compounds are useful as a renin inhibitor.

Morpholine derivative

Fused bicyclic compound having an affinity to mineral corticoid receptor (MR), of formula [I]: wherein ring A is benzene having a substituent R, fused to an adjacent 6-membered heterocyclic ring and further optionally having a substituent(s) other than R, Ris alkylsulfonylamino, etc., Rand Rare (a) the same of different and are hydrogen, alkyl, or optionally substituted aryl, or (b) combined with each other to form an oxo group or (c) combined with each other at its terminal together with the adjacent carbon atom to form cycloalkyl, X is &#x2550;N&#x2014;, &#x2550;C(R)&#x2014; or &#x2014;CH(R)&#x2014;, Ris (a) hydrogen, (b) cyano, (c) halogen, (d) alkyl, (e) alkenyl, (f) cycloalkyl, (g) alkanoyl, (h) carbamoyl, or (i) cycloalkenyl, Ar is an optionally substituted aromatic cyclic group and a dotted line means presence or absence of a double bond, or a pharmaceutically acceptable salt thereof, useful e.g. as an antihypertensive agent.

Fused bicyclic compound

The present invention provides a novel fused bicyclic compound having an affinity to a receptor of mineral corticoid (MR), shown by the formula [I]: wherein the ring A is a benzene ring having a substituent R, fused to an adjacent 6-membered heterocyclic ring and further optionally having a substituent(s) other than R, Ris an alkylsulfonylamino group etc.,

An electric oven such as a toaster oven according to this invention includes in addition to a heating chamber, a heater for the heating chamber and a temperature detector for measuring the temperature therein, a control device serving to automatically determine a target temperature on the basis of the initial temperature inside the heating chamber so that a desired degree of heating can be effected independently of the initial temperature inside the heating chamber by switching off the power supply when the detected temperature reaches the target temperature thus set. According to another embodiment of the present invention, minimum and maximum heating times are set such that the control device will additionally serve to continue the heating independently of the measured temperature if the preset minimum heating time has not elapsed from the beginning of the heating and to shut off the power supply independently of the measured temperature if the preset maximum heating time has elapsed, so that the heating can be effected safely and dependably even if the temperature detector malfunctions.

Toaster oven with initial temperature compensation and sensor check

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Osaka, Japan

Yoichi Takahashi