Japan as Represented by Director General of Agency of Industrial Science

Agency of Industrial Science and Technology

National Institute of Advanced Industrial Science and Technology

Yoichi Taguchi

Akihiro Oishi

Isao Shibuya

Tohru Tsuchiya

Yoshikazu Ikeda

Takashi Masuda

Ken-ichi Fujita

Kazuo Nakayama

Yutaka Ishigami

Masahiko Yasumoto

Hisae Nakahara

Shinichi Kinugasa

Touru Tsuchiya

Katsumi Yonemoto

Kazumasa Honda

A simple and efficient method is proposed for the preparation of a &bgr;-lactam compound such as 1-phenyl-4-ethoxy-2-azetidinone which can be produced by mixing an isocyanate compound such as phenyl isocyanate and a vinyl ether compound such as ethyl vinyl ether and heating the mixture at a moderate temperature under a superatmospheric pressure of up to 12000 atmospheres.

Method for the preparation of &bgr;-lactam compound

Disclosed is a novel, high molecular weight aliphatic polyester having excellent mechanical strengths such as breaking strain and containing a copolymer structure with 3-alkoxy-1,2-propane diol and a method of producing the aliphatic polyester in an industrially advantageous manner. The aliphatic polyester is a biodegradable high molecular weight aliphatic polyester having an ester structure derived from 3-alkoxy-1,2-propane diol.

Biodegradable high molecular weight polyester and method of preparing same

Biodegradable aliphatic copolyester and method of preparing same

A process of producing a polyester or copolyester, wherein at least one cyclic lactone of the following formula (I):

Aliphatic polyester and process for the production thereof

Disclosed is a novel .beta.-lactam compound, a 7-substituted-2-oxa-7-azabicyclo�3.2.0!heptan-6-one represented by the general formula ##STR1## in which R is an alkyl, cycloalkyl, aryl, halogen-substituted aryl or alkaryl group, having usefulness as an intermediate for the synthesis of various biologically active compounds. The compound can be prepared by the reaction of an isocyanate compound RNCO, R being the same as above, and 2,3-dihydrofuran, preferably, under pressurization up to 2000 atmospheres or higher.

7-substituted-2-oxa�3.2.0!heptan-6-one compound and method for the

A novel and simple method is proposed for the synthetic preparation of an N,N-disubstituted .beta.-ketothioamide compound represented by the general formula

Method for the preparation of .beta.-ketothioamide compound

Disclosed is a method for the preparation of a .beta.-thiolactam compound, i.e. a 7-substituted-2-oxa-7-azabicyclo [3.2.0]-heptan-6-thione, represented by the general formula ##STR1## in which R is an alkyl or aryl group, having usefulness as an intermediate for the synthesis of various biologically active compounds. The compound can be prepared by the reaction of an isothiocyanate compound R--NCS, R being the same as above, and 2,3-dihydrofuran, preferably, under pressurization up to 2000 atmospheres or higher at an elevated temperature.

Method for the preparation of .beta.-thiolactam compound

Disclosed is a novel .beta.-lactam compound, a 7-substituted-2-oxa-7-azabicyclo[3.2.0]heptan-6-one represented by the general formula ##STR1## in which R is an alkyl, cycloalkyl, aryl, halogen-substituted aryl or alkaryl group, having usefulness as an intermediate for the synthesis of various biologically active compounds. The compound can be prepared by the reaction of an isocyanate compound RNCO, R being the same as above, and 2,3-dihydrofuran, preferably, under pressurization up to 2000 atmospheres or higher.

7-Substituted-2-oxa-7-azabicyclo [3.2.0.]heptan-6-one compound and

There is disclosed a method for producing 2,6-bis(disubstituted amino)-1,3,5-thiadiazine-4-one compounds represented by formula (I). The method comprises reacting an N,N-disubstituted cyanamide represented by formula (II) with carbonyl sulfide represented by formula (III) under a high pressure. Formula (I) ##STR1## wherein R.sub.1 and R.sub.2 each represent an alkyl group or R.sub.1 and R.sub.2 may bond together to form a ring, Formula (II) ##STR2## wherein R.sub.1 and R.sub.2 each have the same meanings as in formula (I), Formula (III)

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Tsukuba, Japan

Yoichi Taguchi