Yamanouchi Pharmaceutical Company Ltd.

Yoichi Setoguchi

Hiroitsu Kawata

Hiroyoshi Shiozawa

Tadamasa Kawase

Makoto Uchida

Hideyuki Kishimoto

Kenichi Muraoka

Yoshimi Hashimoto

Hisamoto Komatsu

A solid pharmaceutical composition for oral administration comprising a histamine H.sub.2 -receptor antagonist, a low neutralizing capacity antacid, and a high neutralizing capacity antacid coated with a pH-independent and water-insoluble polymer base, which composition improves the condition of a patient promptly after administration and sustains the effects for an extended period of time in the treatment of digestive disorders on which suppression of gastric acid secretion is effective.

H.sub.2 -Receptor antagonist and antacid composition

A granular composition of difficultly digestible polysaccharides (dietary fiber) is composed of a combination of one or more difficultly digestible polysaccharides selected from polysaccharides derived from roots of the plant such as glucomannan, polysaccharides derived from fruits of plants such as pectin, polysaccharides derived from seaweeds such as galactomannan, carragheenin, alginic acid, etc., various kinds of celluloses, and various kinds of brans and one or more difficultly digestible polysaccharides selected from alginates, alginic acid esters, agar, carboxymethyl cellulose salts, and pulullan. The granular composition of this invention is useful as a dietary food or dietary food additive.

Granular composition of difficult digestible polysaccharides

Growing community of inventors

Shizuoka, Japan

Yoichi Setoguchi