Waseda University

Kabushiki Kaisha Yakult Honsha

Yoichi Nakao

Yasuyuki Goto

Daisuke Arai

Noboru Inoue

Shintaro Ishigami

Shigetaka Asano

Teppei Shimomoto

Yukari Kase

Shin-ichiro Kawazu

Using the cobblestone area (CA) formation inhibitory activity of human leukemic stem cell-like cells as an indicator, a fraction having the activity has been extracted from the fat-soluble fraction of Porifera, then, a compound having the activity has been isolated and purified from the aforementioned fraction, and then, the structure thereof has been determined, so that a Stelliferin compound comprising a novel compound has been identified. Moreover, it has been found that the isolated and purified Stelliferin compound significantly suppresses the niche formation of leukemic stem cell-like cells derived from human chronic myelogenous leukemia (CML) having resistance to existing antitumor agents and enhances the effects of antitumor agents on the cells. The present invention provides a pharmaceutical composition having inhibitory or suppressive activity against the niche formation of leukemic stem cells, a prophylactic agent against the recurrence of malignant tumor, which involves the combined use of other antitumor drugs, and the like.

Marine organism-derived extract, compound, and medical composition having niche formation suppressing activity of leukemic stem cells

The object is to develop an antiprotozoal remedy having a novel mechanism of action. Provided is a compound represented by a chemical formula (1), a prodrug or a pharmaceutically acceptable salt thereof, wherein within the formula (1), Rrepresents R&#x2014; of formula (4) or R&#x2014; of formula (5); Rrepresents CHO&#x2014;, etc.; Rrepresents a hydrogen atom, CH&#x2014;C(&#x2550;O)&#x2014;, etc.; Rrepresents a hydrogen atom, CH&#x2014;C(&#x2550;O)&#x2014;, etc.; each of Rand Rindependently represents a hydrogen atom, a methyl group, etc.; Rrepresents &#x2014;CH&#x2014;, &#x2014;CH(&#x2014;OH)&#x2014; or &#x2014;C(&#x2550;O)&#x2014;; each of Rand Rindependently represents a hydrogen atom, a methyl group, etc.; Rrepresents &#x2014;CH&#x2014;, &#x2014;CH(&#x2014;OH)&#x2014; or &#x2014;C(&#x2550;0)&#x2014;; and Rrepresents a hydrogen atom, a hydroxyl group, a methyl group, etc.

Antiprotozoal compound derived from coelenterata

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Shinjuku-ku, Japan

Yoichi Nakao