Sumitomo Chemical Company, Limited

Yoichi Hara

Yoshio Suzuki

Shigeru Okano

Toshihiko Hibino

Etsuro Sato

Novel benzothiazole derivatives of the formula ##SPC1## Wherein R.sub.1 and R.sub.2 are individually hydrogen, lower alkyl, nitro, halogen, optionally substituted amino, carboxyl, lower alkoxy-carbonyl or di-lower alkyl-carbamoyl; and R.sub.3 and R.sub.4 are individually hydrogen, lower alkyl or .alpha.-lower alkyl-benzyl or NR.sub.3 R.sub.4 is a saturated heterocyclic ring containing a nitrogen atom, and their salts. They are useful as antihypertensives.

Benzothiazole derivatives

This invention relates to thiazole derivatives of the formula (I): ##EQU1## wherein R.sub.1 and R.sub.2 are each hydrogen, lower alkyl, cycloalkyl, optionally substituted aryl or optionally substituted heteroaromatic rings containing oxygen, sulfur, nitrogen or combinations thereof, and R.sub.3 and R.sub.4 are each hydrogen or lower alkyl and salts thereof. The thiazole derivatives of the formula (I) have excellent pharmacological properties such as .beta.-adrenergic receptor blocking effects and are valuable compounds exerting preventive or therapeutic effects on heart diseases, for example, arrhythmia, coronary heart disease, etc.

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Toyonaka, Japan

Yoichi Hara