Eisai R&d Management Co., Ltd.

Sogo Pharmaceutical Co., Ltd.

Yohei Tanaka

Yuta Suzuki

Kenji Hyodo

The present invention provides a cationic lipid which can be used for nucleic acid delivery to a cytoplasm and which is possible to solve the problem of physical stability of a lipid complex. This cationic lipid is a compound represented by the general formula (3) or a pharmaceutically acceptable salt thereof: wherein, L is an alkyl having 7-12 carbon atoms or an alkenyl having 7-12 carbon atoms, R is an alkyl having 1-2 carbon atoms, and nand nare independently an integer of 1-3.

Cationic lipid

The present invention provides a cationic lipid which can be utilized for nucleic acid delivery into the cytoplasm. The cationic lipid of the present invention is, for example, a compound represented by the following Formula (1) or a pharmaceutically acceptable salt thereof. 

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Nakama, Japan

Yohei Tanaka