Komatsu Corporation

Astellas Pharma Gmbh

Kotobuki Pharmaceutical Co Ltd

Yohei Seki

Ryo Sato

Takashi Kamikubo

Takeyuki Nagashima

Hiroshi Tomiyama

Akio Kamikawa

Kenichi Kawaguchi

Eiji Kawaminami

Masataka Ozaki

Sunao Imada

Hisao Hamaguchi

Tomoyoshi Imaizumi

Hideyuki Watanabe

Osamu Ikeda

Keiichiro Okuyama

Toru Asano

Kazuyuki Kuramoto

Ikumi Kuriwaki

Yoshinori Iwai

Akihiko Nakamura

Kei Ohnuki

Shinji Soga

Mitsuaki Okumura

Kota Imanishi

Michinori Akaiwa

Hiroki Fukudome

Kozo Miyasaka

Kazuo Kurosawa

Takuya Washio

Hiroki Ishioka

Takashi Chaen

Yinghua Wang

Javier Ramos Miguelez

Chulwon Kwon

Rika Hoshi

Koji Aoshima

An antibody-drug conjugate of formula (I) or salt thereof of formula I: may have Ab as an anti-CLDN6 antibody or an antigen-binding fragment thereof. The antibody-drug conjugate of formula (I) may be (a) an antibody-drug conjugate comprising Ab bound to 1-{3-[(3S)-4-[(4-{[2-amino-4-(pentylamino)-5H-pyrrolo[3,2-d]pyrimidin-5-yl]methyl}-3-methoxyphenyl)methyl]-3-(fluoromethyl)piperazin-1-yl]-3-oxopropyl}-1H-pyrrole-2,5-dione, (b) an antibody-drug conjugate comprising Ab bound to {(2S)-1-[(4-{[2-amino-7-chloro-4-(pentylamino)-5H-pyrrolo[3,2-d]pyrimidin-5-yl]methyl}-3-methoxyphenyl)methyl]pyrrolidin-2-yl}methyl[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl]carbamate, (c) an antibody-drug conjugate comprising Ab bound to N-[(4-{[2-amino-4-(pentylamino)-5H-pyrrolo[3,2-d]pyrimidin-5-yl]methyl}-3-methoxyphenyl)methyl]-N-cyclopropyl-3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propenamide, or (d) an antibody-drug conjugate comprising Ab bound to 1-{3-[(3R)-4-[(4-{[2-amino-4-(pentylamino)-5H-pyrrolo[3,2-d]pyrimidin-5-yl]methyl}-3-methoxyphenyl)methyl]-3-(fluoromethyl)piperazin-1-yl]-3-oxopropyl}-1H-pyrrole-2,5-dione.

Antibody-drug complex containing toll-like receptor 7/8 dual agonist compound

A compound useful as an active ingredient of a pharmaceutical composition for treatment of cancer related to activation of immune cells or cancer having resistance to anti-PD-1 antibody/anti-PD-L1 antibody therapy is provided. The present inventors have conducted studies on a compound useful as an active ingredient of a pharmaceutical composition for treatment of cancer related to activation of immune cells or cancer having resistance to anti-PD-1 antibody/anti-PD-L1 antibody therapy, and found that a pyridazinyl-thiazolecarboxamide compound has DGK ξ (DGKzeta) inhibitory effect, leading to completion of the present invention. The pyridazinyl-thiazolecarboxamide compound of the present invention has DGK ξ inhibitory effect, and can be used as a therapeutic agent for treatment of cancer related to activation of immune cells or cancer having resistance to anti-PD-1 antibody/anti-PD-L1 antibody therapy.

Pyridazinyl-thiazolecarboxamide compound

A compound useful as an active ingredient of a pharmaceutical composition for treatment of cancer related to activation of immune cells or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy is provided. The present inventors have conducted studies on a compound useful as an active ingredient of a pharmaceutical composition for treatment of cancer related to activation of immune cells or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy, and confirmed that a heteroaryl carboxamide compound has DGK ξ (DGKzeta) inhibitory effect, leading to completion of the present invention. The heteroaryl carboxamide compound of the present invention has DGK ξ inhibitory effect, and can be used as a therapeutic agent for treatment of cancer related to activation of immune cells or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy.

Heteroaryl carboxamide compound

A work machine control device includes a measurement-data acquisition unit that acquires measurement data of a three-dimensional measurement device that is mounted on a work machine including work equipment and measures a three-dimensional shape including a ridgeline of a work target on which the working equipment performs work, and a target calculation unit that calculates and outputs, based on the measurement data regarding the ridgeline of the work target, a distance from the work machine to the work target or an angle of repose of the work target.

Work machine control device, excavating machine control device, and work machine control method

A loading machine control device includes a measurement data acquisition unit acquiring measurement data of a measurement device mounted in a loading machine having working equipment, a target calculation unit calculating, based on the measurement data, a position of an upper end portion of a loading target to which an excavation object excavated by a bucket of the working equipment is loaded, a bucket calculation unit calculating position data of the bucket, an overlap determination unit determining whether the upper end portion of the loading target and the bucket that are in the measurement data overlap each other, and a working equipment control unit controlling the working equipment based on the measured position of the upper end portion of the loading target when it is determined that the upper end portion of the loading target and the bucket that are in the measurement data do not overlap each other.

Loading machine control device and loading machine control method

A control device for a loading machine includes a measurement data acquisition unit that acquires measurement data of a measurement device mounted on the loading machine that includes working equipment, a target calculation unit that extracts, from the measurement data, loading target data being measurement data on a loading target on which excavated material excavated by the working equipment is loaded and calculates, based on the loading target data, height data indicating a height of an upper end portion of the loading target and distance data indicating a distance from the loading machine to the loading target, and a working equipment control unit that controls the working equipment based on the height data and the distance data.

Control device for loading machine and control method for loading machine

A work machine includes: a vehicle body front part to which a front wheel is attached; a vehicle body rear part which is coupled to the vehicle body front part through an articulated mechanism and to which a rear wheel is attached; a working equipment coupled to the vehicle body front part; a headlight supported by the vehicle body front part and arranged above the front wheel; and a three-dimensional measurement device arranged on an outer side of the headlight in a vehicle width direction that is in parallel with a rotation axis of the front wheel.

Work machine

Growing community of inventors

Tokyo, Japan

Yohei Seki