Tokyo University of Science Foundation

Chiralgen, Ltd.

Yohei Nukaga

Takeshi Wada

Tatsuya Saito

Yuka Ishii

Rintaro Hara

Reijiro Yoshino

Provided is a polymerizable compound represented by a Formula E-1 or Formula E-2 shown in the description. In Formula E-1 or Formula E-2, Rrepresents an alkoxy group, —NR, a hydroxy group, an aryl group, or an alkyl group, wherein Reach independently represents a hydrogen atom or an alkyl group having 1 to 10 carbon atoms; n represents an integer from 1 to 5; Rrepresents a hydrogen atom, an acetyl group, a phenoxyacetyl group, a pivaloyl group, a benzyl group, a 4-methoxybenzyl group, a benzoyl group, a triphenylmethyl group, a 4,4′-dimethoxytrityl (DMTr) group, a 4-methoxytrityl (MMTr) group, a 9-phenylxanthenyl group, a trimethylsilyl group, a cyanomethoxymethyl group, a 2-(cyanoethoxy)ethyl group, or a cyanoethoxymethyl group; and X represents a structure represented by any one of Formula B-1 to Formula B-5 shown in the description.

Polymerizable compound, compound, and method for producing boranophosphate oligomer

Provided a polymerizable compound represented by the following Formula A-1 or Formula A-2: In Formula A-1 or Formula A-2, Rrepresents an electron-donating group; n represents an integer from 1 to 5; Rrepresents a hydrogen atom, a halogen atom, or &#x2014;OR, wherein Rrepresents a hydrogen atom, an alkyl group, or a protecting group of a hydroxy group; Rrepresents a hydrogen atom or a protecting group of a hydroxy group; and X represents a structure represented by any one of Formula B-1 to Formula B-5.

A method for preparing a phosphorothioate RNA based on the oxazaphospholidine method, wherein cyanoethoxymethyl group is used instead of tert-butyldimethylsilyl group as a protective group of 2'-hydroxyl group of RNA.

Growing community of inventors

Chiba, Japan

Yohei Nukaga