Showa Denko K.k.

Other

Yohei Kurata

Shinobu Ito

Eiji Ogata

Hirobumi Aoki

Harumi Kamachi

Tsutomu Nozawa

Keisuke Mano

Naoaki Misu

Yutaka Oonishi

Takami Ooe

Yoshimasa Ishimura

Yoshihiro Sugi

Yoshihiro Kubota

Takaaki Hanaoka

Hideaki Hamada

Hirotsugu Nakanishi

A skin agent for external use and a cosmetic agent are provided, by transdermal administration of which expected actions and effects of ubiquinone derivatives, salts thereof, ubiquinones and ubiquinols are effectively obtained. The skin agent for external use includes a ubiquinone derivative or a salt thereof as an active ingredient. The ubiquinone derivative is represented by the formula (1): wherein Rand Rare each a hydrogen atom or a phosphoric group, at least one of Rand Ris a phosphoric group, and n is an integer in the range of 1 to 9.

Skin agent for external use and cosmetic agent including ubiquinone derivative or salt thereof and method using the same

To provide novel carnitine derivatives and salts thereof that are resistant to hydrolysis in the presence of aqueous media, and also provide external skin preparations and cosmetics that are excellent in storage stability, product life, skin affinity and percutaneous absorption properties. In particular, to provide novel &#x3b1;-branched acyl carnitine derivatives and salts thereof, external skin preparations and cosmetics comprising specific &#x3b1;-branched acyl carnitine derivatives and/or salts thereof.

Carnitine derivative, salt thereof, external skin preparation and cosmetic material

A process is provided for preparing zeolite, particularly &lsqb;Al&rsqb;-SSZ-31, which comprises the steps of providing a mixture of a zeolite source, an aluminum-containing material, an organic structure directing substance, preferably at least one selected from the group consisting of N,N&prime;-bis-triethyl-1,6-hexanediyl-diammonium dihydroxide, N,N&prime;-bis-triethyl-1,7-heptanediyl-diammonium dihydroxide, N,N&prime;-bis-triethyl-1,8-octanediyl-diammonium dihydroxide, N,N&prime;-bis-triethyl-1,9-nonanediyl-diammonium dihydroxide, N,N&prime;-bis-triethyl-1,10-decanediyl-diammonium dihydroxide, and their salts, and water; drying said mixture to form a powdered dry gel; and contacting and reacting said dry gel with steam at a saturated vapor pressure to produce an aluminum-containing zeolite &lsqb;Al&rsqb;-SSZ-31.

Preparation of zeolite

Disclosed herein are a highly purified tocopheryl phosphate and/or a salt thereof (tocopheryl phosphates) wherein a P,P'-bistocopheryl hypophosphate and/or a salt thereof (P,P'-bistocopheryl diphoshates) is contained in a proportion of not higher than 3% by weight; a process for producing a highly purified tocopheryl phosphate and/or a salt thereof, which comprises the steps of reacting a tocopherol with an oxyphosphorus trihalide followed by treating with an acid or basic aqueous solution to thereby form tocopheryl phosphates (i) in which P,P'-bistocopheryl diphoshates (ii) formed as by-products are contained, hydrolyzing the P,P'-bistocopheryl diphoshates (ii) under acid condition, and, optionally, rendering the hydrolyzate neutral or basic under basic condition; and a method of analyzing tocopheryl phosphates, comprising analyzing a sample containing components (i) and (ii) with the use of a high-performance liquid chromatograph column packed with a gel of a polymethacrylate having, bonded thereto, long-chain alkyl groups. None or only an extremely minute amount of P,P'-bistocopheryl diphoshates are contained in the highly purified tocopheryl phosphates, so that the highly purified tocopheryl phosphates exhibit antioxidant and blood circulation promoting effects, have excellent water solubility, are powdery so that the handling thereof is extremely easy, are free from cutaneous irritation and allergenecity and ensure dermal safety. Therefore, the highly purified tocopheryl phosphates are useful as cosmetic ingredients. The amounts of components (i) and (ii) can be simply measured with high accuracy by the above method.

Highly purified tocopheryl phosphate, process for producing the same,

High-  purity tocopherol phosphates, process for the preparation

A method for producing L-ascorbic acid 2-phosphates, is disclosed which comprises phosphorylating L-ascorbic acid whose hydroxyl groups at the 5- and 6-positions are unprotected or protected with a protective group, or salts thereof, with a phosphorus oxyhalide to form corresponding L-ascorbic acid 2-phosphates, wherein a reaction mixture obtained after the phosphorylation reaction is heated to convert by-products derived from L-ascorbic acid into L-ascorbic acid, which again is subjected to the phosphorylation reaction with the phosphorus oxyhalide. The method produce L-ascorbic acid 2-phosphates in a high yield and at a high purity with simple operations.

Method for producing L-ascorbic acid 2-phosphates

Growing community of inventors

Kawasaki, Japan

Yohei Kurata