Sumitomo Dainippon Pharma Co., Ltd.

Sumitomo Pharma Co., Ltd.

Dainippon Sumitomo Pharma Co., Ltd.

The Kitasato Institute

Yohei Ikuma

Junya Ikeda

Andrew Simon Bell

Hidefumi Yoshinaga

Jeremy Besnard

Satoshi Adachi

Shuji Masumoto

Yoshinori Aihara

Nobuhisa Fukuda

Harunobu Mitsunuma

Kengo Tojo

Ryo Fukazawa

Hiroyuki Nakahira

Toshiaki Sunazuka

Toshio Kanai

Hidenori Kimura

Sachiko Koike

Shingo Mizushima

Shunichiro Uesugi

Hitoshi Suda

Yoshihiko Noguchi

Yuki Mizukami

Masato Iwata

Satoshi Suetsugu

Yoshio Nakai

Takayuki Fukaya

Kozo Yoshida

Kiyoto Sawamura

Takashi Takada

Kuniko Suzuki

Chongkwang Lee

Akira Fusano

The present invention relates to a medicament for treating neuropsychiatric diseases, comprising a compound of Formula (1): or a pharmaceutically acceptable salt thereof, as an active ingredient.

Substituted pyrazoles showing serotonin 5-HT receptor activity

A process for preparing a compound of Formula (1a):

Process for preparing substituted pyrazolo[1,5-a]pyrazines

Provided is a novel compound that has an excellent &#x3b2;-lactamase inhibitory effect. More specifically, provided is a compound represented by formula (1a), (1b) or (11) having an excellent &#x3b2;-lactamase inhibitory effect or a pharmaceutically acceptable salt thereof. By using this compound either in combination with a &#x3b2;-lactam drug or alone, a useful preventive or therapeutic agent for bacterial infections is provided. Also provided are useful preventive or therapeutic agents for treating various diseases with the combined use of the aforesaid compound and &#x3b2;-lactam drugs.

Oxo-substituted compound

Provided are a compound that is useful for the prevention of and/or as a treatment agent for a disease in which a group II mGlu receptor is involved; and a medical application of said compound. Provided is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof. 

Substituted pyrazolo[1,5-a]pyrazines as negative allosteric modulators of group II metabotropic glutamate receptor

Substituted lactams showing serotonin 5-HT receptor activity

Condensed lactam derivative

A compound represented by formula (1) (in the formula: ring-D represents a three- to eight-membered hydrocarbon ring; Rrepresents an optionally substituted amino Calkyl group or the like; Rand Reach independently represent a hydrogen atom, a halogen atom, or the like; Rrepresents an optionally substituted Caryl group or the like; Rrepresents a hydrogen atom or the like; and ring-Q represents a (hetero)aryl group or the like which may be substituted with a carboxyl group or the like) or a pharmaceutically acceptable salt thereof exhibits an excellent FXIa inhibitory activity, and is useful as a therapeutic agent against thrombosis or the like. 

1-(cycloalkyl-carbonyl)proline derivative

Provided are condensed 5-oxazolidinone derivatives and pharmaceutically permissible salts thereof, which have excellent anticoagulant effects, are well absorbed orally, and are useful as therapeutic drugs for thrombosis, etc. Compounds represented by formula (1) and pharmaceutically permissible salts thereof. [In the formula, L represents a C-Calkylene group that may be substituted; Rand Reach independently represent a hydrogen atom or C-Calkyl group, etc. that may be substituted; Xrepresents N or CR; Rand Reach independently represent a hydrogen atom, halogen atom, or C-Calkyl group; Rrepresents a C-Ccycloalkyl group, etc. that may be substituted; and Rrepresents a hydrogen atom, etc.]

Condensed 5-oxazolidinone derivative

The present invention provides a compound of formula (I): wherein Ris optionally substituted Calkyl, etc.; Ris hydrogen atom, etc.; G, G, Gand Gare (i), etc. ((i) Gis &#x2014;N(R)&#x2014;, Gis &#x2014;CO&#x2014;, Gis &#x2014;C(R)(R)&#x2014;, and Gis oxygen, etc.); Ris optionally substituted Calkyl, etc.; Rand Rare each independently optionally substituted Calkyl, etc.; Ris optionally substituted Calkyl, etc.; R, R, Rand Rare each independently a group: -A-B (A is a single bond, etc., B is hydrogen atom, etc.), etc.; n is 1, etc.; Ris Calkoxycarbonyl, etc., or a pharmaceutically acceptable salt thereof, which is useful as a renin inhibitor.

N-substituted-cyclic amino derivative

The present invention relates to a compound of the following formula (I) or a pharmaceutically acceptable salt thereof, being useful as a renin inhibitor. [wherein Ris halogen, etc.; Ris H, etc.; Gis &#x2014;N(R)&#x2014;, etc.; Gis &#x2014;CO&#x2014;, etc.; Gis &#x2014;C(R)(R)&#x2014;, etc.; Gis oxygen, etc.; Ris optionally substituted Calkyl, etc.; Rand Rare independently the same or different, H, etc.; Ris H, optionally substituted Calkyl, etc.; R, R, Rc and Rare independently the same or different, and a group: -A-B (said A is single bond, etc., and said B is H, etc.), etc.; and n is 1, etc.]

Bicyclic heterocyclic derivative

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Osaka, Japan

Yohei Ikuma