Nipro Corporation

Yohei Hoashi

Toshiya Kai

Makoto Sato

Naohisa Katayama

Takao Okada

Yukari Imamura

Yoshimichi Fujiyama

Tatsuaki Miyaji

Tamaki Murayama

Shunsuke Daidouji

Hisae Saito

Shiho Sakuragi

Noami Ohmichi

A method for easily producing orodispersible tablets that secure an eluting behavior of a principal agent in the digestive tract and mask unpleasant taste in the oral cavity is provided. Provided is a method for producing orodispersible tablets which includes mixing an additive to a principal agent to form principal agent particles as a granulation process, coating the principal agent particles with a coating agent to form coated particles as a coating process, and tableting the coated particles to form tablets as a tableting process, wherein the additive used in the granulation process contains a pH regulator, and the coating agent used in the coating process contains a pH-dependent polymer dissolving at pH 5 or more.

Method for producing orodispersible tablets

A bioabsorbable release-sustaining pharmaceutical formulation using a biodegradable release-sustaining base material which can prevent an effective component drug from being released too rapidly just after administration of the formulation and then allow continued release of the drug for at least one month at a defined rate, is provided. For the biodegradable release-sustaining base material, a lactic acid-glycolic acid copolymer (PLGA) with an adjusted distribution in molecular weight is used.

Bioabsorbable pharmaceutical formulation

Growing community of inventors

Osaka, Japan

Yohei Hoashi