Pfizer Corporation

Yogesh Sabnis

Christoph Martin Dehnhardt

Peter M Jones

Jotham Wadsworth Coe

Gavin Alistair Whitlock

Florian Michel Wakenhut

Paul Anthony Stupple

Karl Richard Gibson

Mark David Andrews

William Howson

Thomas Ryckmans

David Graham Brown

Christelle Lauret

Sharanjeet Kaur Bagal

Sarah Elizabeth Skerratt

Kiyoyuki Omoto

Wolfgang Klute

Steven Wade Kortum

Stuart Nicholas Comlay

Joanne Clare Hannam

Inaki Morao

Steven Wade Korturn

The present invention relates to compounds of Formula (I) and their pharmaceutically acceptable salts, wherein the substituents are as described herein, and their use in medicine, in particular as Trk antagonists.

Pyrrolo[3,2-c]pyridine tropomyosin-related kinase inhibitors

A method of treating a disease or condition for which a JAK inhibitor is indicated in a subject in need of such treatment, comprising administering to the subject a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or pharmaceutically acceptable salt, and particularly, a method for the treatment of various inflammatory diseases, particularly psoriasis, asthma and COPD.

Indazoles

The present invention relates to compounds of formula (I): to pharmaceutically acceptable salts therefore and to pharmaceutically acceptable solvates of said compounds and salts, wherein the substituents are defined herein; to compositions containing such compounds; and to the uses of such compounds in the treatment of various diseases, particularly asthma and COPD.

The present invention relates to compounds of the formula (I) or a tautomer or prodrug thereof, or a pharmaceutically acceptable salt of said compound, tautomer or prodrug, wherein:

Antiparasitic agents

Growing community of inventors

Sandwich, United Kingdom

Yogesh Sabnis