Zumutor Biologics Inc.

Yogendra Manjunath B M

Maloy Ghosh

Vivek Halan

Sunit Maity

Kavitha Iyer Rodrigues

Bharath Ravindra Shenoy

Sanghamitra Bhattacharjee

Divya Unnikrishnan

Sohang Chatterjee

Bhargav Prasad

Sankaranarayanan Srinivasan

Anuradha Hora

Karthika Nair

Aswini Thanigaivel

Amol Maliwalave

Pavithra M

Pravin Kumar D

Sathyabalan M

Veeresha K

Bairavabalakumar N

Rajeshwari Pendse

Prabhat Kumar Pathak

Anisha Kurup

Sahana Bhima Rao

Jahnabi Hazarika

Jahnabi Arika

The present disclosure relates to a method of obtaining a cell where fucosylation pathways are modified, leading to production of partially fucosylated and non-fucosylated protein products, specifically antibodies from the cell. The present disclosure employs the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology. The method of the present disclosure targets the Fut8 gene and GMD gene in a cell. Such products are used in developing therapeutics and biomarkers, and in diagnosis and prognosis of diseases.

DNA-binding domain of CRISPR system, non-fucosylated and partially fucosylated proteins, and methods thereof

The present disclosure relates to developing cell lines where specific biological pathways are modified, particularly by modifications in the enzymes of the cell. The present disclosure develops protein expression systems wherein specific modification of glycan chain of the protein is achieved, which produces non-fucosylated proteins, including non-fucosylated antibodies. The non-fucosylated proteins are used in developing therapeutic monoclonal antibodies and biomarkers, and in diagnosis and prognosis of various diseases. The present disclosure employs the Transcription Activator like Effector Nuclease (TALEN) technology for inactivating fucosylation in a cell.

Non-fucosylated protein and methods thereof

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Bengaluru, India

Yogendra Manjunath B M