H. Lee Moffitt Cancer Center and Research Institute, Inc.

University of South Florida

Yoganand Balagurunathan

Robert J Gillies

Dmitry B Goldgof

Lawrence O Hall

Dung-Tsa Chen

Mokenge P Malafa

Robert A Gatenby

Jennifer Permuth

Olya Stringfield

Jung Wook Choi

John Arrington

Natarajan Raghunand

Daniel Jeong

The present invention concerns materials and methods for identifying and classifying pancreatic ductal adenocarcinoma (PDAC) precursors or intraductal papillary mucinous neoplasm (IPMN) using messenger RNAs, microRNAs, long non-coding RNAs, radiomic features, radiologic measures of abdominal/visceral obesity, and combinations thereof, as diagnostic markers for integration with clinical management and interventions for personalized care.

Theranostic tools for management of pancreatic cancer and its precursors

Virtually every cancer patient is imaged with CT, PET or MRI. Importantly, such imaging reveals that tumors are complex and heterogeneous, often containing multiple habitats within them. Disclosed herein are methods for analyzing these images to infer cellular and molecular structure in each of these habitats. The methods can involve spatially superimposing two or more radiological images of the tumor sufficient to define regional habitat variations in two or more ecological dynamics in the tumor, and comparing the habitat variations to one or more controls to predict the severity of the tumor.

Radiologically identified tumor habitats

Growing community of inventors

Tampa, FL, United States of America

Yoganand Balagurunathan