Posco

Postech Foundation

Postech Academy-industry Foundation

Pohang University of Science and Technology Foundation

Dong-a University Research Foundation for Industry-academy Cooperation

Yoe-Sik Bae

Sung-Ho Ryu

Pann-Ghill Suh

Ji-Young Song

Youn-Dong Kim

Eun-Young Park

Yoon-Keun Kim

Sung Ho Ryu

Taehoon Lee

Tae-Hoon Lee

Jong-young Kwak

Hyunjoo Bae

Richard D Ye

Young-Chul Sung

You-Suk Seo

Hyun-Kyu Kang

Jung-Im Kim

Eun Jin Jo

Ha Young Lee

Tae Hoon Lee

Sang-Doo Kim

The present invention relates to an immunoregulating agent comprising a peptide, a pharmaceutical composition and a method of preventing or treating immune-related disorder such as sever sepsis or acute respiratory distress syndrome (ARDS), and the use of peptide for anti-inflammatory agent, an antibacterial agent, or an inhibiting agent of an immune cell apoptosis.

Composition and method for preventing and treating immune-related disorder

Disclosed are peptides having SEQ ID NOs: 1 to 24 that induce superoxide generation by human monocytes or neutrophils; that induce an intracellular calcium increase by human peripheral blood monocytes or neutrophils; binds to formyl peptide receptor or formyl peptide receptor-like 1; that induce chemotactic migration of human monocytes or neutrophils in vitro; that induce degranulation in formyl peptide receptor expressing cells or formyl peptide receptor-like 1 expressing cells; that stimulate extracellular signal regulated protein kinase phosphorylation via activation of formyl peptide receptor or formyl peptide receptor-like 1; or that stimulate Akt phosphorylation via activation of formyl peptide receptor or formyl peptide receptor-like 1.

Immune-modulating peptide

The present application discloses W-rich peptide that is useful for inhibiting FPR class receptor activity.

Peptides that antagonize FPR class receptor mediated signaling

The present application describes peptides that stimulate arachidonic acid release in target cells. The application also discloses peptides that cause intracellular calcium release. The application also discloses methods of using the disclosed peptides.

Leukocyte stimulating peptides

Disclosed are peptides having SEQ ID NOs: 1 to 32 that can stimulate superoxide generation in human monocytes. Superoxide is the most important armory on the primary defense line of monocytes against invading pathogens, and the identification of new stimuli and the characterization of the regulatory mechanism of superoxide generation are of paramount importance.

Immune-enhancing peptides

The present application describes peptides that stimulate arachidonic acid release in target cells. The application also discloses peptides that cause intracellular calcium release.

A vaccine having a good vaccination effect, which comprises an antigen; a peptide selected from the group consisting of a peptide having the amino acid sequence of SEQ ID NO: 1, a peptide having the amino acid sequence of SEQ ID NO: 2, and a peptide derived from a peptide having the amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 2; and an immune activator.

Vaccine composition containing a promoter peptide

Growing community of inventors

Busan, South Korea

Yoe-Sik Bae