Bio-rad Laboratories, Inc.

Yochanan Uri

Boaz Ran

Itay Barak

Ariel Notcovich

Evan Thrush

Shay Nimri

Shai Nimri

Govind V Kaigala

Robert Dean Lovchik

Steve Swihart

James W Hillendahl

Kevin McDonald

David P Taylor

Steven Swihart

Tal Rosenzweig

Ariel Shemesh

Michael Kanevsky

Barak Abraham Liraz

Marcel Buerge

Uri Issman

Igor Kochetkov

Shai Aharon

The present disclosure is notably directed to a microfluidic probe head (), or MFP head, comprising a processing surface () having liquid injection and liquid aspiration apertures, as well as projections () extending from the processing surface (). The arrangement of injection and aspiration apertures provides for a hydrodynamic flow confinement within a processing region that is formed between the processing surface () and a substrate () or sample surface (for example, the bottom of a microtiter plate sample well ()), typically located beneath the processing surface (). The disclosure is further directed to related microfluidic probe devices, and methods of operation of such an MFP head, notably to deposit cells on a surface.

Microfluidic probe head with aspiration posts

An instrument for detecting signal from a biological sample includes a pipettor module configured to hold a plurality of pipettes in respective pipette positions, to hold liquid in one or more pipette tips, and to pipette liquid in and out of the one or more pipette tips. Each of the one or more pipette tips has a pipette tip point. The instrument further includes one or more magnets positioned such that each of the one or more pipette tips is adjacent one of the one or more magnets.

Automated immunoassay

Horizontal gel electrophoresis devices and methods of extracting a gel from a gel housing are provided. The devices allow for extraction of gels without having to open the housing comprising the gel. The devices include gel cassettes that simplify the automation of gel electrophoresis and electroblotting of proteins. Also provided are devices that allow for horizontal gel electrophoresis without the need to from a liquid seal between the buffer reservoir and the gel housing. Also described are methods for extracting a gel from a housing without opening the housing.

Horizontal electrophoresis separation device without seal and method of extracting gel without opening cassette

Devices, systems, methods, and kits for contact imaging are provided. A contact imaging device includes an imaging sensor, a fixed fiber faceplate mechanically coupled to the imaging sensor, and an optical filtering layer mechanically coupled to the fixed fiber faceplate. The optical filtering layer can include an interference filter, an absorptive filter, and/or a removable fiber faceplate. The contact imaging device can be used to image fluorescent samples by filtering out excitation light on the basis of wavelength and/or angle of incidence.

Contact imaging devices for fluorescence applications

A tip for use in an optical detection system to analyze an analyte in a fluid sample drawn into the tip, using light reflected from a detection surface inside the tip that the analyte binds to, comprising a first detection surface and a second detection surface located in a same flow path with no controllable valve separating them, wherein the first and second detection surfaces have different surface chemistries.

Optical detection system for liquid samples

Provided herein are imaging cassettes for detecting a luminescent and/or radioactive signals. Such cassettes are useful in common biological assays, e.g., immunoassays, nucleotide detection assays, and other affinity assays.

Contact imager

An SPR or other optical resonance based analysis system in which, light is provided at multiple angles to a specimen and then the light modified by the specimen is processed to select only some of the light. Optionally, the processing selects light at a particular incidence angle. Optionally, the detection is by imaging of the light on a 2D imager array.

Optical resonance analysis using a multi-angle source of illumination

Growing community of inventors

Givat Ela, Israel

Yochanan Uri