Sankyo Company, Limited

Yo Takiguchi

Jun Ohsumi

Hidehiko Furukawa

Tokio Tani

Yasuo Shimoji

Kazuhiko Sasagawa

Ichiro Kawashima

Toshinori Ohmine

Mutsuo Nakajima

Tatsuo Haneishi

Masatoshi Inukai

Mamoru Arai

Hiroshi Mishima

Shinjiro Yamamoto

Masaki Nakahara

Michiya Terao

Ohmine, Toshinori

Jun Ohsuri

Kawashima, Ichiro

Yasuhiro Itoh

Human pancreatic elastase can now be obtained from a genetically engineered source.

Human pancreatic elastase

Compounds of formula (I): ##STR1## [in which: Y represents a group of formula ##STR2## the dotted line is a double of single bond; R.sup.1 is hydrogen, alkyl or aryl; R.sup.2 is hydrogen or halogen; R.sup.3 is alkyl or cycloalkyl; R.sup.4 is hydrogen, alkyl, hydroxy or halogen; and R.sup.6 is hydrogen, optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, or aralkyl;] and pharmaceutically acceptable salts thereof are valuable in the treatment of cachexia. Certain of these compounds are novel.

Method of treating cachexia and certain new compounds for use in this

Compounds of formula (I): ##STR1## and pharmaceutically acceptable salts thereof are valuable in the treatment of cachexia.

Method of treating cachexia

Human pancreatic elastase I can be obtained by genetic engineering.

Human pancreatic elastase I

A new compound, named 'Compound B-41D', has the formula: ##STR1## and can be prepared by cultivating a microorganism of the genus Streptomyces, especially Streptomyces strain B-41-146. Compound B-41D has valuable acaricidal and anthelmintic activities.

Fermentation process for producing compound having anthelmintic and

New antibiotic substances named substance No. 17927A.sub.2 and substance No. 17927A.sub.1 produced by cultivation of substances No. 17927A.sub.2 and No. 17927A.sub.1 -producing microorganisms belonging to the genus Streptomyces as well as pharmaceutically-acceptable salts thereof. They have broad antibacterial activities and also .beta.-lactamase inhibitory action so that they show synergistic actions with known penicillins and cephalosporins.

Antibiotic substances No. 17927A.sub.1 and No. 17927A.sub.2 and process

Growing community of inventors

Tokyo, Japan

Yo Takiguchi