Washington University

Disarm Therapeutics, Inc.

Yo Sasaki

Jeffrey D Milbrandt

Toshiyuki Araki

Aaron DiAntonio

Kow Essuman

Xianrong Mao

Rajesh Devraj

Robert Owen Hughes

Raul Eduardo Krauss

Tong Wu

Dan Summers

Adam Bloom

Yurie Yamada

Amy Strickland

Aaron Diantonio

Jian Zhu

Among the various aspects of the present disclosure is the provision is the provision of a SARM1 activating agent or prodrug thereof and methods of using same.

Neurolytic agents and methods of using and identifying same

The present invention provides compounds useful as inhibitors of TIR NADase activity, compositions thereof, and methods of using the same. The present invention is useful for inhibition of TIR-domain NADase activity and/or treating microbial infection and/or modulating microbial physiology.

Identification of inhibitors of TcpC and TIR NADase activity

The present disclosure provides compounds useful as inhibitors of SARM1 NADase activity, compositions thereof, and methods of using the same. The present disclosure provides compounds useful for treating a neurodegenerative or neurological disease or disorder, compositions thereof, and methods of using the same.

Inhibitors of SARM1 NADase activity and uses thereof

Methods of treating or preventing axonal degradation in neuropathic diseases in mammals are disclosed. The methods can comprise administering to the mammal an effective amount of an agent that acts by increasing sirtuin activity in diseased and/or injured neurons. The methods can also comprise administering to the mammal an effective amount of an agent that acts by increasing NAD activity in diseased and/or injured neurons. Also disclosed are methods of screening agents for treating a neuropathies and recombinant vectors for treating or preventing neuropathies.

Methods and compositions for treating neuropathies

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St. Louis, MO, United States of America

Yo Sasaki