Navix International Limited

Yizhaq Shmayahu

Yitzhack Schwartz

Eli Dichterman

Shlomo Ben-Haim

Zalman Ibragimov

Yehonatan Ben David

Haim Rodriguez

Yaara Yarden

Shlomo Ben-haim

In some embodiments, a body cavity shape of a subject is reconstructed based on intrabody measurements of voltages by an intrabody probe (for example, a catheter probe) moving within a plurality of differently-oriented electromagnetic fields crossing the body cavity. In some embodiments, the method uses distances between electrodes as a spatially calibrated ruler. Positions of measurements made with the intrabody probe in different positions are optionally related by using spatial coherence of the measured electromagnetic fields as a constraint. Optionally, reconstruction is performed without using a detailed reference (image or simulation) describing the body cavity shape. Optionally, reconstruction uses further information to refine and/or constrain the reconstruction; for example: images, simulations, additional electromagnetic fields, and/or measurements characteristic of body cavity landmarks. Optionally, reconstruction accounts for time-dependent cavity shape changes, for example, phasic changes (e.g., heartbeat and/or respiration), and/or changes in states such as subject hydration, edema, and/or heart rate.

Systems and methods for reconstruction of intra-body electrical readings to anatomical structure

Devices and methods for tissue lesion assessment and/or creation based on dielectric properties are disclosed. In some embodiments, one or more probing frequencies are delivered via electrodes including an electrode in proximity to a tissue (for example, myocardial tissue). Measured dielectric properties (such as impedance properties), optionally together with other known and/or estimated tissue characteristics, are used to determine the lesion state of the tissue. In some embodiments, a developing lesion state is monitored during treatment formation of a lesion (for example, ablation of heart tissue to alter electrical transmission characteristics).

Lesion assessment by dielectric property analysis

There is provided a method of displaying a pre-acquired three dimensional (3D) image of at least a portion of an organ of a patient, the method comprising: receiving a plurality of electrical readings, each from a different electrode mounted on a catheter inside the portion of the organ of the patient, wherein the electrodes are mounted on the catheter at known distances from each other, transforming the plurality of electrical readings to a corresponding plurality of image points using a mapping transformation that transforms each electrical reading of the catheter from inside the portion of the organ of the patient to an anatomically corresponding image point in the 3D image based on the known distances, and displaying the 3D image with a marking of at least one of the plurality of image points.

Systems and methods for registration of intra-body electrical readings with a pre-acquired three dimensional image

In some embodiments, data sensed and/or operational parameters used during a catheterization procedure are used in the motion frame-rate updating and visual rendering of a simulated organ geometry. The organ geometry is rendered as a virtual material using a software environment (preferably a graphical game engine) which applies simulated optical laws to material appearance parameters affecting the virtual material's visual appearance, as part of simulating a scene comprising the simulated organ geometry, and optionally also comprising simulated views of a catheter probe used for sensing and/or treatment. Optionally, measurements of and/or effects on tissue by sensing and/or commanded probe-tissue interactions are converted into material appearance changes, allowing dynamic visual simulation of intra-body states and/or events based on optionally non-visual input data. In some embodiments, physiology, motion physics, and/or other physical processes are simulated based on live inputs as part of associating material appearance properties to the simulated tissue's geometry.

Real-time display of treatment-related tissue changes using virtual material

Methods for estimating of the effectiveness of catheter ablation procedures to form lesions, and particular lesions which together form an ablation segment of an ablation line. Lesion effectiveness parameters are received, and effectiveness, optionally the joint effectiveness, of corresponding ablations (optionally planned, current, and/or already performed) is estimated. In some embodiments, estimating is based on use by computer circuitry of an estimator constructed based on observed associations between previously analyzed lesion effectiveness parameters, and observed lesion effectiveness. Additionally or alternatively, estimators may be constructed based on analytic functions. The estimator is used by application to the received lesion effectiveness parameters.

Estimation of effectiveness of ablation adjacency

Disclosed herein is a method of graphically presenting an indicating marker over a 3-D model of a tissue surface during a catheterization procedure, comprising determining a region over the 3-D model, deforming the indicating marker to congruently match a shape defined by the 3-D model across the region at a plurality of positions; and rendering the 3-D model into an image including the deformed indicating marker by generating an image of the 3-D model covered by said deformed indicating marker.

Tissue model dynamic visual rendering

Methods for estimating of the effectiveness of catheter ablation procedures to form lesions. Lesion effectiveness parameters are received, and effectiveness of a corresponding ablation (optionally planned, current, and/or already performed) is estimated. The estimating is based on use by computer circuitry of an estimator constructed based on observed associations between previously analyzed lesion effectiveness parameters, and observed lesion effectiveness. The estimator is used by application to the received lesion effectiveness parameters.

Estimators for ablation effectiveness

In some embodiments, a body cavity shape of a subject is reconstructed based on intrabody measurements of at least one property of an electromagnetic field by an intrabody probe (for example, a catheter probe) moving within a plurality of electrical fields intersecting the body cavity. In some embodiments, the electrical fields are generated at least in part from electrodes positioned in close proximity, for example, within 1 cm, of the body cavity. In some embodiments, the body cavity is a chamber of a heart (for example, a left atrium or left ventricle), and the electrodes used to generate the electrical field are positioned in the coronary sinus, a large vein occupying the groove between the left atrium and left ventricle. In some embodiments, known distances between measuring electrodes are used in guiding reconstruction, potentially overcoming difficulties of reconstruction from measurements of non-linear electrical fields.

Coronary sinus-based electromagnetic mapping

Display screen or portion thereof with icon

A method of estimating a spatial relationship between at least a part of a patient esophagus and a heart chamber, including: measuring at least one electric parameter at one or more positions within the heart chamber to obtain measured values; and estimating the spatial relationship based on the measured values.

Esophagus position detection by electrical mapping

Systems and methods for reconstruction of intrabody electrical readings to anatomical structure

In some embodiments, data sensed and/or operational parameters used during a catheterization procedure are used in the motion frame-rate updating and visual rendering of a simulated organ geometry. In some embodiments, measurements of and/or effects on tissue by sensed and/or commanded probe-tissue interactions are converted into adjustments to the simulated organ geometry, allowing dynamic visual simulation of intra-body states and/or events based on optionally partial and/or non-visual input data. Adjustments to geometry are optionally to 3-D positions of simulated data and/or to simulated surface properties affecting geometrical appearances (e.g., normal mapping). Optionally, the organ geometry is rendered as a virtual material using a software environment (preferably a graphical game engine) which applies simulated optical laws to material appearance parameters affecting the virtual material's visual appearance. Optionally, physiology, motion physics, and/or other physical processes are simulated based on live inputs, as part of assigning geometrical adjustments to the simulated tissue.

Growing community of inventors

Ramat-Hasharon, Israel

Yizhaq Shmayahu