Ngm Biopharmaceuticals, Inc.

Genentech, Inc.

Alamar Biosciences, Inc.

Yiyuan Yin

Yan Wang

Wenwu Zhai

Zhonghao Liu

Paul J Carter

Michael Patrick Dillon

Yuling Luo

Christoph Spiess

Jie Tang

Jianhui Zhou

Jacob Corn

Dana Yen Mei Duey

Xunshan Ding

Shiping Chen

Wei Feng

Chun Chu

Adrian Grzybowski

Jared Martin Higbee

Avi J Ashkenazi

Junichiro Sonoda

Mark Chen

Wendy N Sandoval

Wendy Sandoval

Disclosed herein are highly sensitive immunoassays that utilize a capture/release mechanism to reduce non-specific binding and achieve detection with attomolar-level sensitivity. Kits that can be used for carrying out these highly sensitive immunoassays are also disclosed herein.

Nucleic acid linked immune-sandwich assay (NULISA)

Provided are, inter alia, multispecific antigen binding proteins, or antigen-binding fragments thereof, comprising one or more mutations in the VH/VL domains and/or CH1/CL domains, pharmaceutical compositions comprising same, isolated nucleic acids, vectors, and host cells encoding/expressing same, method of making the multispecific antigen binding proteins, computer readable media for evaluating multispecific antigen binding proteins, and libraries.

Multispecific antigen-binding proteins

The present disclosure provides binding agents, such as antibodies (including single chain variable fragments), that specifically bind complement component C3, including human C3, compositions comprising same, and methods of their use. The disclosure also provides related polynucleotides and vectors encoding the binding agents and cells comprising same.

C3-binding agents and methods of use thereof

The present disclosure provides binding agents, such as antibodies, that specifically bind Angiopoietin-like protein 8 (ANGPTL8), including human ANGPTL8, and methods of their use.

Methods of lowering triglyceride levels with an ANGPTL8-binding antibody or antigen-binding fragment thereof

Anti-C3 antibodies

ANGPTL8-binding agents and methods of use thereof

The invention provides dual specific anti-FGFR2 and FGFR3 (FGFR2/3) antibodies, and compositions comprising and methods of using these antibodies.

Anti-FGFR2/3 antibodies and methods using same

Growing community of inventors

Fremont, CA, United States of America

Yiyuan Yin