Global Blood Therapeutics, Inc.

Dracen Pharmaceuticals, Inc.

Huawei Technologies Co., Limited

Yiyang Shao

Zhe Li

Pavel Majer

George Yiannikouros

Nathan Guz

Markus Frieser

Jon Philip Lawson

Liang Liao

Robert Christian Wild

Jinchao Weng

Jinxiao Chu

Julieana Cocuz

Wei Wang

Kai Zheng

Bin He

Lukáš Tenora

Ivan Šnajdr

Martin Hadzima

A controlling data packet sending method. The method for controlling data packet sending includes: obtaining a plurality of control models, where the plurality of control models corresponds to a plurality of conditions; selecting, based on a first condition, a first control model corresponding to the first condition from the plurality of control models, the first control model is used to process a transmission parameter of any network in at least one network; processing, by using the first control model, a transmission parameter of a first network accessed by an end node, to obtain a first control parameter required for sending the data packet of the first application by the end node by using the first network; and controlling sending of the data packet of the first application based on the first control parameter.

Method and apparatus for controlling data packet sending, model training method and apparatus, and system

The present disclosure provides methods of preparing a compound of Formula (I): wherein R, R, and Rare as defined as set forth in the application. In one embodiment, a compound of Formula (I) is prepared in >95% chemical purity and >95% enantiomeric excess.

Method of preparing a DON prodrug from L-glutamic acid

The present disclosure provides a method of preparing a compound of Formula I, wherein Ris C-Calkyl; Ris C1-C4 alkyl; and Ris selected from the group consisting of C-Calkyl, (aryl)alkyl, and (heteroaryl)alkyl in &#x3e;95% chemical purity and &#x3e;95% enantiomeric excess.

Method of preparing a DON prodrug from L-pyroglutamic acid

Disclosed herein are processes for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde (also referred to herein as Compound (I)) and intermediates used in such processes. Compound (I) binds to hemoglobin and increases it oxygen affinity and hence can be useful for the treatment of diseases such as sickle cell disease.

Process for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde

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Beijing, China

Yiyang Shao