Portland State University

The Oregon State Board of Higher Education on Behalf of Portland State University

Yixing Guo

Robert Michael Strongin

Mark Allen Lowry

Lovemore Hakuna

Jorge Omar Escobedo Córdova

Robert M Strongin

Probes for selectively detecting compounds comprising a thiol group and an amino group ('thiols') are disclosed. Exemplary thiols include cysteine, homocysteine, and glutathione. Embodiments of the disclosed probes produce a detectable change in absorbance spectrum and/or emission spectrum when reacted with one or more thiols in solution. Methods and kits for performing the detection also are disclosed. The probes have a general formula where each bond depicted as '' is a single or double bond; R, R-Rand Rindependently are hydrogen, hydroxyl, thiol, lower alkyl, carboxyalkyl, amino, alkoxy, or halogen; Ris an &#x3b1;,&#x3b2;-unsaturated aliphatic ester; Ris oxygen, sulfur, hydrogen, hydroxyl, thiol, lower alkyl, carboxyalkyl, amino, alkoxy, or halogen, or Rand Rtogether form a cycloalkyl or aryl ring; Xis CH, S, NH, O, Se, Si(CH), Ge(CH), Sn(CH), or C(CH); and Xis CH, CH, N, NH, or CRwhere Ris aryl.

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Marlborough, MA, United States of America

Yixing Guo