Guangzhou Henovcom Bioscience Co. Ltd

Yiwu Wu

Jiancun Zhang

Deyao Li

Yiqian Zhou

Yan Liu

Provided are a long-acting prodrug of Rasagiline, which has application in the treatment of Central Nervous System diseases such as Parkinson's disease, preparation method and use thereof. The long-acting prodrug of Rasagiline has a structure of formula (I), wherein T is absent, or T is selected from each of Rand Ris independently selected from H, D, and alkyl; W is absent, or W is selected from (CH), wherein n is an integer selected from 1 to 15; X is absent, or X is selected from (CH), wherein m is an integer selected from 1 to 10; Y is absent, or Y is selected from &#x2014;C(&#x2550;O)NH&#x2014;, &#x2014;NHC(&#x2550;O)&#x2014;; Ris selected from substituted or unsubstituted C-Calkyl, substituted or unsubstituted C-Calkenyl, substituted or unsubstituted C-Calkynyl, substituted or unsubstituted C-Ccycloalkyl, cholane aliphatic group, &#x2014;R&#x2014;C(&#x2550;O)O&#x2014;R, &#x2014;R&#x2014;OC(&#x2550;O)&#x2014;R, &#x2014;R&#x2014;C(&#x2550;O)NH&#x2014;R, &#x2014;R&#x2014;NHC(&#x2550;O)&#x2014;R, &#x2014;R&#x2014;S(&#x2550;O)O&#x2014;Rand &#x2014;R&#x2014;OS(&#x2550;O)&#x2014;R. 

Long-acting prodrugs of rasagiline, preparing methods and uses thereof

Provided are a long-acting prodrug of Entecavir, preparation method and use thereof, wherein the prodrug of Entecavir has a structure of formula I. The prodrug of Entecavir can be released slowly, sustainably and steady, and converted to active compound of Entecavir to achieve a long-acting effect.

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Guangzhou, China

Yiwu Wu