Massachusetts Institute of Technology

Momenta Pharmaceuticals, Inc.

Yiwei Qi

Ganesh Venkataraman

Mallikarjun Sundaram

Zachary Shriver

Ram Sasisekharan

Dongfang Liu

Ishan Capila

Nur Sibel Gunay

Daniela Beccati

Corinne Bauer

Cuihua Liu

Yiming Yao

Thomas Richardson

Michele Picard

Pat Oliver-Shaffer

Zainab Sirajbhai Mamuwala

Ian David Fier

Ying Li

Preparations of low molecular weight heparins (LMWHs) having improved properties, e.g., properties that provide a clinical advantage, are provided herein. Methods of making and using such preparations as well as methods of analyzing starting materials, processing, intermediates and final products in the production of such LMWH preparations are provided.

Low molecular weight heparin composition and uses thereof

The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.

Methods for analyzing a heparin sample

The invention relates to methods and products for analyzing or processing a heparin sample. In one embodiment, the methods comprise contacting the sample with heparinase I, heparinase II and heparinase III, determining the amount of a signature component in the sample using a separation method, and making a determination about the sample based upon a comparison of the amount of the signature component in the sample to a reference database for a heparin.

Methods for analyzing or processing a heparin sample

The invention relates to methods for delivering polysaccharides by a pulmonary route to achieve local and systemic therapeutic effects. The polysaccharides may be formulated or unformulated and in some instances have an extremely fast absorption rate.

Methods and products related to pulmonary delivery of polysaccharides

The invention relates, in part, to methods and products related to producing low molecular weight heparin.

Methods and producing low molecular weight heparin

Methods for evaluating the quality of a heparin sample

Formulation for pulmonary delivery of a therapeutic, prophylactic, or diagnostic agent including a low molecular weight heparin and a therapeutic, prophylactic, or diagnostic agent.

Polysaccharides for pulmonary delivery of active agents

Methods and products related to evaluating the quality of a polysaccharide

Methods and products related to the analysis of polysaccarides

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Andover, MA, United States of America

Yiwei Qi