Georgetown University

Sepracor, Inc.

Yiwang Chen

James W Young

Raymond L Woosley

Methods and compositions are disclosed utilizing metabolic derivatives of terfenadine for the treatment of allergic disorders while avoiding the concomitant liability of adverse effects associated with the terfenadine. The metabolic derivatives of terfenadine are also useful for the treatment of retinopathy and other small vessel disorders associated with diabetes mellitus and such other conditions as may be related to the antihistamine activity of terfenadine. For example, the metabolic derivatives of terfenadine are useful for the treatment of asthma, motion sickness, and vertigo, without the concomitant liability of adverse effects associated with terfenadine. Furthermore, the metabolic derivatives of terfenadine, in combination with non-steroidal anti-inflammatory agents or other nonnarcotic analgesics, or in combination with a decongestant, cough suppressant/antitussive or expectorant, are useful for the treatment of cough, cold, cold-like, and/or flu symptoms and the discomfort, headache, pain, fever, and general malaise associated therewith, without the concomitant liability of adverse effects associated with terfenadine.

Growing community of inventors

Silver Spring, MD, United States of America

Yiwang Chen