Worcester Polytechnic Institute

Vivascan Corporation

University of Massachusetts

Cybro Medical, Inc.

Boston Scientific Scimed, Inc.

Spectramed, Inc.

Yitzhak Mendelson

Hannu Harjunmaa

Yi Wang

Raymond M Dunn

Robert A Peura

Brian D Gross

Yoram Wasserman

Mark W Boden

Sandra Nagale

Charles E Beuchat

Guy Russell Lowery

Byron L Moran

Glenn R Gaudette

John A McNeill

Allan F Willis

Deanna Cavallaro

Arriyan Samandar Dowlatshahi

Asaf Danzinger

Tristan Richardson

Karen Mendelson

Tyler Hickey

Dennis Giaya

Rami Shuraim

Rebecca Stolarczyk

Dervis Goksun

Systems, devices, and methods of the present application relate to the diagnostic measurement of condition for pressure ulcers. Preferred embodiments utilize pressure measurements at body locations to determine a diagnostic pressure ulcer value. A pressure sensor device generates patient pressure data that is processed by a data processor which utilizes a diagnostic function to determine the diagnostic value that indicates whether corrective action is needed to prevent pressure ulcer formation. One or more sensor devices can be attached to a patient to measure to transmit data for further processing.

Systems and methods for prevention of pressure ulcers

The present invention relates to devices and methods for measuring vascular deficiency using Doppler ultrasound detection. Embodiments can be used to monitor the condition of surgical tissue flaps or other conditions in which obstruction in the vascular system can impact patient health. The systems can include a Doppler ultrasound probe, a color probe, a temperature probe, and/or other suitable probes to measure blood volume and perfusion status of a tissue region. The systems and methods can be used to monitor flaps after flap transplant surgeries. The systems and methods can automatedly assess tissue condition and alert the patient or medical staff if the condition has fallen below a threshold indicating occlusion of a blood vessel. One or more additional sensors can be integrated into a probe to measure vascular conditions and a metric can be computed based on sensed data.

Devices and methods for measuring vascular deficiency

The present disclosure relates to the field of tissue mapping and ablation. Specifically, the present disclosure relates to expandable medical devices for identifying and treating local anatomical abnormalities within a body lumen. More specifically, the present disclosure relates to systems and methods of focal treatment for overactive bladders.

Systems and methods for mapping and ablation in the bladder

A holder for a sensor includes a body having a top wall and a side portion extending away from the top wall. The sensor is adapted to sense a parameter of an item. The top wall and the side portion of the body form an interior cavity. A flange is coupled to and extends away from an edge of the side portion. A pressure application portion is coupled to a surface of the interior cavity of the body and is adapted to apply force to the sensor when the holder is coupled to the surface of the item.

Preloaded sensor holder

A sensor for use in an optical measurement device and a method for non-invasive measurement of a blood parameter. The sensor includes sensor housing, a source of radiation coupled to the housing, and a detector assembly coupled to the housing. The source of radiation is adapted to emit radiation at predetermined frequencies. The detector assembly is adapted to detect reflected radiation at least one predetermined frequency and to generate respective signals. The signals are used to determine the parameter of the blood.

Pulse oximeter and method of operation

Carbon Monoxide (CO) is a colorless, tasteless, and odorless gas which causes asphyxiation by combining with a strong affinity to blood hemoglobin. Unless a patient is quickly identified as having CO poisoning, the patient could face severe medical consequences including death. This patent describes a reagentless optical method for measuring carboxyhemoglobin (HbCO) in a whole undiluted blood sample that can be obtained from a fingerstick. A battery-operated triple wavelength device measures light transmission at frequencies of 548 nm, 810 nm and 950 nm through a 40 .mu.L sample of undiluted whole blood placed in standard disposable glass capillary tube. Having a portable point-of-care device, for uses by paramedics during an emergency situation, in the emergency room, or in a physician's office, can provide accurate immediate confirmation of CO poisoning.

Optical method and apparatus for measuring carbon monoxide in

The present invention relates to the determination of an analyte or multiple analytes in blood using information derived from the differential optical absorption spectra of blood. Specifically, the information is derived from the differential spectra of tissue before and immediately after the volume of blood in the tissue has been changed.

Blood constituent determination based on differential spectral analysis

The present invention relates to the noninvasive measurement of blood hematocrit and hemoglobin content using differential optical absorption of two or more wavelengths of light during blood volume changes. The method is also useful for noninvasive measurements of other blood analytes, such as glucose, where variations in hematocrit or blood hemoglobin concentration cause errors in the measurement.

Noninvasive measurement of hematocrit and hemoglobin content by

To deterine glucose or other constituents of the human or animal body, near-infrared radiation containing two alternating wavelengths that have equal extinction coefficients in the tissue is directed onto a sample area of the body. The intensity relation of the two different wavelengths is adjusted so as to balance the two wavelength detected signals. The extracellular-to-intracellular fluid ratio of the tissue is changed or is allowed to change, and the alternating component of the transmitted beam power is measured. The amplitude of the alternating-current (AC) signal given by the detector represents glucose concentration or the difference from a preset reference concentration.

Electromagnetic method and apparatus to measure constituents of human or

To determine glucose or other constituents of the human or animal body, a stabilized near-infrared radiation beam containing two alternating wavelengths that have approximately equal extinction coefficients in the tissue, is directed onto the sample area, the transmitted signal alternating component is zeroed by tuning one of the wavelengths, the extracellular-to-intracellular fluid ratio of the tissue is changed by exerting varying mechanical pressure on the tissue, or the ratio is allowed to change as a result of the natural pulsation. The alternating component of the transmitted beam power is measured in the changed fluid ratio state. The amplitude of the alternating-current (AC) signal given by the detector, is taken to represent glucose concentration or the difference from a preset reference concentration.

A non-invasive system for measuring the concentration of an analyte, such as glucose, in an absorbing matrix is described. The system directs beams of light at the matrix using an analyte sensitive wavelength and an analyte insensitive wavelength. The principles of photoplethysmography are applied to measure the change in light intensity caused by matrix absorption before and after the blood volume change caused by the systolic phase of the cardiac cycle. The change in light intensity is converted to an electrical signal which is used to adjust the light intensity and as a measure of analyte concentration.

Method and apparatus for monitoring blood analytes noninvasively by

A non-invasive system for measuring the concentration of an analyte in an absorbing matrix is described. The system directs a beam of radiation at the matrix. The beam consists of a series of successive alternate pulses of electro-magnetic radiation, one of which is highly absorbed by the analyte and the other of which is non-absorbed. The transmitted or reflected beam is optically detected and an electrical signal proportional to beam intensity is used to adjust the beam intensity and as a measure of analyte concentration.

Method and apparatus for measuring the concentration of absorbing

An optical fiber carries a light beam through a cardiovascular catheter and projects the beam into the patient's bloodstream. Two other fibers, spaced in a very carefully controlled configuration from the first, receive light scattered by corpuscles (and blood-vessel walls) and transmit this reflected light back through the catheter to respective detectors outside the patient's body. If preferred, two input fibers and a single output fiber--or other techniques for providing differential geometry--may be used instead. Electronic instrumentation finds the ratio of the two light fluxes, thus cancelling out unknown variables such as input light intensity and optical--connector attenuation. The known differential geometry between the two light paths permits calibration of the ratio measurement in terms of corpuscular concentration--i.e., hematocrit. Light at only one wavelength suffices for the measurement. Advanced forms of the invention correct for proximity of blood-vessel walls. This system is particularly compatible with optical-fiber measurements of oxygen saturation, as either or both of the light paths already provided may be used for the oxygen reflectometry.

Growing community of inventors

Worcester, MA, United States of America

Yitzhak Mendelson