Palatin Technologies Incorporated

Yiqun Shi

Shubh D Sharma

Wei Yang

Annette M Shadiack

Ramesh Rajpurohit

Zhijun Wu

Kevin D Burris

Hui-Zhi Cai

Papireddy Purma

A method of modulating energy homeostasis in a mammal without eliciting a sexual response by administration of a therapeutically effective amount of a pharmaceutical composition including a melanocortin receptor compound of the formula: where Ris a bond or a linker unit including from one to six backbone atoms and an unsubstituted naphthalene group, and L, R, Rand Rare as defined in the specification.

Naphthalene-containing melanocortin receptor-specific small molecule

A thienopyrimidine compound of the formula: wherein R, R, R, and Rare as defined herein, and methods of use of such compounds for the treatment of melanocortin receptor-associated disorders.

Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds

Metallopeptides and metallopeptide combinatorial libraries specific for melanocortin receptors are provided, for use in biological, pharmaceutical and related applications. The metallopeptides and combinatorial libraries are made of peptides, peptidomimetics and peptide-like constructs, in which the peptide, peptidomimetic or construct is conformationally fixed on complexation of a metal ion-binding portion thereof with a metal ion.

Melanocortin metallopeptide constructs, combinatorial libraries and applications

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East Brunswick, NJ, United States of America

Yiqun Shi