Guangzhou Henovcom Bioscience Co. Ltd

Yiqian Zhou

Jiancun Zhang

Deyao Li

Qi Guo

Lijun Zhang

Yiwu Wu

Kun Wang

Yan Liu

Jufu Zhang

Huajin You

Chen Guo

Jiafeng Chen

Suyong Li

Huixuan Chen

Yanhui Liu

Feng Wu

Wanjun Tang

Xiaoxi He

A novel tetrahydronaphthalene compound is provided, or a stereoisomer, a solvate, a pharmaceutically acceptable salt thereof, or a pharmaceutical composition including the compound, and a use of the compound or the composition for preparing a medicament in prevention and/or treatment of a central nervous system disease, wherein the compound has a structure of formula (I), wherein each of X, Y, Z, W and R is defined as described in the present disclosure.

Tetrahydronaphthalene compounds, pharmaceutical compositions, and uses thereof

The present disclosure relates to compounds for RNA capping and uses thereof, which belong to the technical field of genetic engineering. Compounds of formula I can result in high levels of capping efficiency, and the capped mRNA exhibits a high transcription level and increased expression.

Compounds for RNA capping and uses thereof

Provided are a long-acting prodrug of Rasagiline, which has application in the treatment of Central Nervous System diseases such as Parkinson's disease, preparation method and use thereof. The long-acting prodrug of Rasagiline has a structure of formula (I), wherein T is absent, or T is selected from each of Rand Ris independently selected from H, D, and alkyl; W is absent, or W is selected from (CH), wherein n is an integer selected from 1 to 15; X is absent, or X is selected from (CH), wherein m is an integer selected from 1 to 10; Y is absent, or Y is selected from &#x2014;C(&#x2550;O)NH&#x2014;, &#x2014;NHC(&#x2550;O)&#x2014;; Ris selected from substituted or unsubstituted C-Calkyl, substituted or unsubstituted C-Calkenyl, substituted or unsubstituted C-Calkynyl, substituted or unsubstituted C-Ccycloalkyl, cholane aliphatic group, &#x2014;R&#x2014;C(&#x2550;O)O&#x2014;R, &#x2014;R&#x2014;OC(&#x2550;O)&#x2014;R, &#x2014;R&#x2014;C(&#x2550;O)NH&#x2014;R, &#x2014;R&#x2014;NHC(&#x2550;O)&#x2014;R, &#x2014;R&#x2014;S(&#x2550;O)O&#x2014;Rand &#x2014;R&#x2014;OS(&#x2550;O)&#x2014;R. 

Long-acting prodrugs of rasagiline, preparing methods and uses thereof

Provided are a long-acting prodrug of Entecavir, preparation method and use thereof, wherein the prodrug of Entecavir has a structure of formula I. The prodrug of Entecavir can be released slowly, sustainably and steady, and converted to active compound of Entecavir to achieve a long-acting effect.

Long-acting prodrugs of entecavir, preparing methods and uses thereof

Growing community of inventors

Guangzhou, China

Yiqian Zhou