Exelixis Patent Company LLC

Exelixis, Inc.

X-Ceptor Therapeutics, Inc.

Yinong Xie

Raju Mohan

Edwin J Schweiger

William C Stevens, Jr

Michael Charles Nyman

Richard Martin

Brett Bradley Busch

Shao Po Lu

Tie-Lin Wang

Brenton Todd Flatt

Xiao-Hui Gu

Alan Thomas Johnson

Haixia Wang

Christopher D Bayne

Shao-Po Lu

Wei Xu

Vasu Jammalamadaka

Brant Clayton Boren

Xiao Hui Gu

Tie Lin Wang

Methods of using compounds of the invention, such as compounds of Formulae IIa, IIb, IIc, or IId and pharmaceutically acceptable salts thereof are disclosed. The compounds are useful in treating, preventing, inhibiting or ameliorating the symptoms of a disease or disorder that is modulated or otherwise affected by nuclear receptor activity, or in which nuclear receptor activity is implicated.

Imidazole based LXR modulators

Compounds of the invention, such as compounds of Formulae Ia, Ib, Ic, or Id and pharmaceutically acceptable salts, isomers, and prodrugs thereof, which are useful as modulators of the activity of liver X receptors, where R1, R2, R21, R3, and G are defined herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed. 

Modulators of LXR

Compounds of the invention, such as compounds of Formulae IIa, IIb, IIc or IId, and pharmaceutically acceptable salts, isomers, and prodrugs thereof, are useful as modulators of the activity of liver X receptors, where R, R, R, Rand G are defined herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed. 

Compounds of the invention, such as compounds of formula (I): 

Compounds of the invention are disclosed, such as compounds of formulae LX-LXIV, and pharmaceutically acceptable salts, isomers, or prodrugs thereof, which are useful as modulators of the activity of liver X receptors (LXR) and Farnesoid X receptors (FXR), where R, R, R, R, J, J, G, G, and Q are defined herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed. 

LXR and FXR modulators

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Yinong Xie