Nanjing Carephar Shenghui Pharmaceutical Co., Ltd.

Jiangsu Carephar Pharmaceutical Co., Ltd.

Jiangsu Carefree Pharmaceutical Co., Ltd

Yinlin Qin

Mei Su

Tao Chen

Jianhua Jiang

Haidong Liu

Qiu Jin

Xi Zong

Xianzhi Wu

Min Ji

Shousheng Yan

The present invention relates to a modulator of 1,2,5-oxadiazole indoleamine-(2,3)-dioxygenase, a preparation method and use thereof, more particularly to compounds of Formula I and Formula II, an isomer thereof, a pharmaceutically acceptable salt or a pharmaceutically acceptable solvate thereof, and their use in preparing drugs for treating cancers, neurodegenerative diseases, eye diseases, mental disorders, depression, anxiety disorders, Alzheimer's diseases and/or autoimmune diseases. Specific meanings of R substituents in Formula I and Formula II are consistent with the description of the specification. 

Modulator of indoleamine 2,3-dioxygenase, preparation method and use thereof

The present invention relates to a new pyrrole sulfonyl derivative, and a preparation method and medical use thereof. In particular, the present invention relates to a pyrrole sulfonyl derivative as represented by general formula (I), a preparation method thereof, a pharmaceutical composition comprising the derivative, and a use thereof as a therapeutic agent, in particular as a gastric acid secretion inhibitor and as potassium-competitive acid blockers (P-CABs), wherein each substituent group of general formula (I) is the same as that defined in the description.

Pyrrole sulfonyl derivative, preparation method and medical use thereof

The invention relates to a 4-substituted pyrrolo[2,3-d]pyrimidine compound and the use thereof in preparing medications for treating JAK-targeted diseases such as rheumatoid, immune system diseases, and tumor. The 4-substituted pyrrolo[2,3-d]pyrimidine compound of the invention is as shown in chemical formula I.  The activity experimental results of the invention show that the new compound has obvious effect and activity in inhibition of Janus kinases, JAK-STAT, cell proliferation of human lymphocytoma, and rheumatoid arthritis.

4-substituted pyrrolo[2,3-d]pyrimidine compound and use thereof

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Jiangsu, China

Yinlin Qin