Nhwa Pharma. Corporation

Huazhong University of Science and Technology

Wuhan Jiayu Technology Co., Ltd.

Yinli Qiu

Guisen Zhang

Yin Chen

Minquan Yu

Xiangqing Xu

Bifeng Liu

Xin Liu

Song Zhao

Guosheng Wu

Qiang Guo

Shicheng Liu

Yu Lan

Tan Zhang

Xudong Cao

Fei Dou

Yifang Zhang

Xiaojun Feng

Aijun Lu

Shuang Zhang

Quxiang Li

Yingying Dong

Peng Jing

Yuanyuan Hou

The present invention relates to the field of pharmaceutical chemistry, and specifically relates to a fused heterocyclic compound derivative and an application thereof. The fused heterocyclic compound derivative has the structure of general formula (I), and can be used to treat neuropsychiatric diseases. 

Fused heterocyclic compound derivative and application thereof

The present invention relates to a lactam compound derivative, a medicine composition comprising the lactam compound derivative, and uses of the composition and the lactam compound derivative in preparation of a medicine for preventing or treating schizophrenia, the lactam compound derivative having a structure as shown in Formula I. 

Lactam compound derivative and application thereof

Disclosed are alicyclic[c]benzopyrone derivatives and use thereof. The alicyclic[c]benzopyrone derivatives are compounds represented by formula I or their salts. The present compounds not only significantly improve high activity induced by MK-801, but also effectively improve clambering symptom induced by Apomorphine and do not cause EPS within effective dose. These in vitro targets and in vivo pharmacological models are closely related to diseases of the nervous system caused by dopamine dysfunction, especially schizophrenia. Therefore the present compounds can be used for the treatment of central nervous system diseases, especially schizophrenia. EDis lower and effect is stronger in two animal models i.e. high activity induced by MK-801 and clambering symptom induced by Apomorphine, while EDis higher and therapeutic index is greater in animal models of catalepsy. 

Alicyclic[c] benzopyrone derivatives and uses thereof

The present invention belongs to the medicinal chemistry field, and specifically discloses a [1,3,4]oxadiazole derivative with the structure of general formula (I) and pharmaceutically acceptable salt thereof. The compound can be used to prepare a medicine for preventing or treating a disease of the central nervous system. 

[1,3,4] oxadiazole derivative and application thereof

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Xuzhou, China

Yinli Qiu