The State University of New York

Yingtian Pan

Hugang Ren

Congwu Du

Nora Volkow

The present invention provides a method of imaging blood vessels or blood flow in blood vessels in an animal comprising:

Intralipid as a contrast agent to enhance subsurface blood flow imaging

In general, in one aspect, the invention features a method that includes using an optical coherence tomography system to acquire a plurality of frames of a sample where each frame includes optical information about the composition of the sample through a section of the sample. The method further includes averaging over two or more of the frames to provide an image of the section of the sample where successive frames of the two or more frames are acquired with a time lapse of 0.05-0.7 seconds. Embodiments of the method may have unique advantages for endoscopic subcellular imaging. For example, they can enable subcellular imaging with low-NA optics (e.g., NA=0.25 or less) while providing morphological imaging of the underlying tissue up to 0.6 mm without focal tracking.

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East Setauket, NY, United States of America

Yingtian Pan