Insilico Medicine IP Limited

Yangtze River Pharmaceutical Group Co., Ltd.

Shanghai Haiyan Pharmaceutical Technology Co., Ltd.

Janssen Pharmaceutica Nv

Yingtao Liu

Luoheng Qin

Xin Cheng

James Patrick Edwards

Yang Liu

Patrick René Angibaud

Qing Shan Zhang

Virginie Sophie Poncelet

Jiong Lan

Olivier Alexis Georges Querolle

Wei Cai

Vineet Pande

Zhao-Kui Wan

Xiang Chen

Fusheng Zhou

Daniel Jason Krosky

Aaron Nathaniel Patrick

Chong Wen

Yunzhou Jin

Liqiang Fu

Xuedong Dai

Jiangwei Wang

Ping Bu

Baoxin Xi

Ming Weng

Leitao Zhang

Pengfei Cheng

Wangbin Sun

Yonggang Chen

Barbara Morschhäuser Geb Herkert

Linglong Kong

Xi Chen

Qing Zhang

The disclosure provides for compounds and methods for modulating or inhibiting glutaminyl-peptide cyclotransferase-like protein (QPCTL). In one aspect, described herein are compounds of Formulas (I), (Ia), (Ib), (Iaa), (Iab), (Iba), (Ibb), (II), (IIa), (IIb), (IIaa) (IIab), (IIba), and (IIbb), stereoisomer thereof, or salts or solvates thereof. Further provided herein are methods of treating a disease or a condition comprising administering a compound of Formula (I), (Ia), (Ib), (Iaa), (Iab), (Iba), (Ibb), (II), (IIa), (IIb), (IIaa) (IIab), (IIba), or (IIbb), a stereoisomer thereof, or a salt or solvate thereof.

Beta-lactam derivatives for the treatment of diseases

Provided are compounds of Formula (I), pharmaceutical compositions comprising such compounds, and their use as menin/MLL protein/protein interaction inhibitors, useful for treating diseases such as cancer, myelodysplastic syndrome (MDS) and diabetes. 

Exo-aza spiro inhibitors of menin-MLL interaction

The present disclosure relates to pyridinamine-substituted heterotricyclo compounds, a preparation method thereof, and a use thereof in medicines. Specifically, a compound of formula (I), or a pharmaceutically acceptable salt, stereoisomer, solvate, or prodrug thereof, a preparation method and a use thereof are disclosed, wherein the groups in the formula (I) are as defined in the Description and claims. 

Pyridylamino substituted heterotricyclic compounds, and preparation method and pharmaceutical use thereof

The present invention relates to a sulfuryl-substituted benzoheterocyclic derivative, a preparation method and medical use thereof. Particularly, disclosed is a compound of formula (I) or a pharmaceutically acceptable salt, stereoisomer, solvate, or prodrug thereof, and a preparation method and application thereof. The definition of each group in the formula can be found in the specification and the claims. 

Sulfuryl-substituted benzoheterocyclic derivative, preparation method and medical use thereof

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Shanghai, China

Yingtao Liu