Genentech, Inc.

Genetech, Inc.

F. Hoffmann-la Roche Ag

F. Hoffmann-la Roche Sa

Yingnan Zhang

Robert A Lazarus

Weiru Wang

Rami Hannoush

Harini Kaluarachchi

Aaron Nile

Cameron Noland

Lijuan Zhou

Xinxin Gao

Yan Wu

Ryan Jefferson Watts

Daniel Kirchhofer

Jasvinder Atwal

Yongmei Chen

Cecilia Pui Chi Chiu

Wei Ey Li

Sachdev Singh Sidhu

Maureen H Beresini

Daniel J Burdick

Nicholas Skelton

Mark Ultsch

Mike Costa

Charles Eigenbrot, Jr

John Quinn

Jacob Corn

Paul M Moran

Rajkumar Ganesan

Aaron H Phillips

Baris Bingol

Sachdev S Sidhu

Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.

Cystine knot scaffold platform

The invention provides PCSK9 inhibitors, compositions comprising the PCSK9 inhibitors, and methods of identifying and using the PCSK9 inhibitors.

Compositions and methods for treating cardiovascular disease

The invention provides antibodies to specific neural proteins and methods of using the same.

Nucleic acid molecules encoding for BACE1 antibodies

The invention provides peptide inhibitors of BACE1 that bind to the active site in a noncanonical fashion, and methods of use thereof.

Peptide inhibitors of BACE1

Methods and compositions for neural disease immunotherapy

Provided herein are conformationally stabilized ubiquitin proteins and methods for using the same to identify agents that bind to the stabilized ubiquitin protein or that bind to a protein that interacts with or processes the stabilized form of the ubiquitin protein. Also provided herein are methods for screening for conformationally stabilized proteins having increased binding affinity to a binding partner in comparison to the binding affinity of the wildtype form of the protein to the binding partner.

Engineered conformationally-stabilized proteins

BACE1 antibodies

The invention provides hepsin antibodies, and compositions comprising and methods of using these antibodies.

Anti-hepsin antibodies and methods using same

The invention provides modulators of Dvl PDZ-ligand interaction, and methods of identifying and using these modulators.

Disheveled PDZ modulators

Growing community of inventors

South San Francisco, CA, United States of America

Yingnan Zhang