Tianjin Institute of Pharmaceutical Research

Tianjin Institute of Pharmaceutical Research Co., Ltd.

Yingmei Han

Guangping Xia

Naxia Zhao

Peng Liu

Lida Tang

Weiren Xu

Wei Liu

Yuli Wang

Yuquan Li

Bingni Liu

Shijun Zhang

Xuyuan Liu

Zhuanyou Zhao

Weiting Wang

Qian Shang

Xiaoli Fu

Weiling Kong

Jing Jin

Xiaohua Kong

Wulin Liu

Provided are a polypeptide derivative, modified derivative or salt thereof, and use of the polypeptide derivative, modified derivative or salt thereof, wherein the polypeptide derivative, modified derivative or salt thereof comprises a polypeptide having the sequence of following general formula I, general formula I: wherein the definitions of X, X, X, X, X, X, X, X, X, X, X, X, X, Xand Xare consistent with the definitions in the claims and the description. The polypeptide derivative provided by the invention has a dual agonistic effect on GC/GLP-1 receptors, so that a synergistic effect on energy metabolism is generated, which can effectively reduce blood glucose while reducing body weight and improving the body fat level, and the efficacy is better than that of a single GLP-1 receptor agonist.

Glucagon-derived peptide and use thereof

This invention provides a method for preparing cycloastragenol monoglucoside CMG (cycloastragenol-6-O-&#x3b2;-D-glucoside), comprising the steps of: a. using astragaloside IV or Astragali extracts prepared by a conventional method as raw materials and adding an appropriate solvent thereinto to form a raw material solution; b. adding hydrolase and allowing for hydrolysis at a constant temperature to obtain a hydrolysate; c. separating the hydrolysate with macroporous adsorption resin; and d. obtaining the product by purification and separation. The present invention further provides cycloastragenol-6-O-&#x3b2;-D-glucoside prepared according to the method of this invention as well as its use in the preparation of a medicament for treating cardiovascular diseases and pharmaceutical compositions comprising the same.

Cycloastragenol monoglucoside, preparation, pharmaceutical composition and application thereof

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Tianjin, China

Yingmei Han