Sunshine Lake Pharma Co., Ltd.

North & South Brother Pharmacy Investment Company Limited

Yingjun Zhang

Qingyun Ren

Siegfried Goldmann

Jiancun Zhang

Xiaojun Wang

Xinchang Liu

Chuanfei Jin

Changhua Tang

Junjun Yin

Kai Yi

Bing Liu

Hongming Xie

Ji Zhang

Changchung Cheng

Zhifu Zou

Xinye Yang

Zheng Gu

Liang Chen

Wenhe Zhong

Guanghua Yan

Shengtian Cao

Huichao Luo

Yibo Lei

Yejun Wang

Jianzhou Huang

Runfeng Lin

Yang Liu

Zongyuan Zhang

Jianyu Liu

Bailin Hu

Junwen Wu

Jinsheng Liang

Jinfeng Xiong

Kangzhi Chen

Panpan Kang

Wuyong Wu

Tong Qu

Weihong Zhang

Yinglin Zuo

Weiming Huang

Li Gao

Chuanwen Yang

Tianzhu Yu

Rongqi Zhou

Shifeng Li

Zhimin Xiong

Changping Fu

Xiwei Wu

Linjin Tu

Jianli Wu

Yumei Tan

Jinlei Liu

Xiaohong Lin

Jihua Lin

Ming Luo

Haiping Liang

Wanjun Tang

Yingchao Cheng

Shaohui Xiong

Shengqiang Pan

Xuli Wang

Changwei Huang

Yi Yu

Rui Guo

Yi Qin Yu

Lu Zhang

Jing Li

Weihua Wang

Xuechen Li

Jiquan Zhang

Tianming Wang

Yu Chen

Zheng Li

Liang Wen

Jianhao Li

Haoxiong Qin

Chao Yi

Hong Chen

Facheng Ma

Jinheng Gao

Chenliang Wu

Desheng Huangfu

Shoutao Wu

Xiaofeng Yuan

Bohua Long

Tianyun Wu

Zhixin Cheng

Runzhi Liu

Xiangyu Zhang

Shiguo Zhang

Hongpeng Xie

Jiancheng Wang

Linlin Nie

Shun Bai

Mingyu Guan

Xuke Li

Fangyuan Wu

Qinghong Fang

You Li

Pharmaceuticals, and specifically a Teixobactin analogue and use thereof. A pharmaceutical composition having the compound and use of the compound and the pharmaceutical composition thereof inhibits the growth and/or reproduction of Gram-positive bacteria or. A compound has Formula (Ia) or a stereoisomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof,

Teixobactin analogue and use thereof

Thienopyrimidine derivative having stereo configurations and use thereof in medicine. Also included are pharmaceutical compositions of the compounds. The compounds or pharmaceutical compositions may be used to inhibit acetyl-CoA carboxylase (ACC). A method for preparing the compounds and the pharmaceutical compositions, and use thereof in treatment or prevention of diseases associated with ACC regulation of mammals, in particular, humans.

Thienopyrimidine derivatives having stereo configurations and use thereof in medicine

A RET inhibitor, a pharmaceutical composition thereof and uses thereof. In particular, the present invention provides a compound having Formula (I) or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof. The invention also relates to a pharmaceutical composition including the compound, and uses of the compound and pharmaceutical composition thereof for the preparation of a medicament, in particular for treatment and prevention of RET-related diseases and conditions, including cancer, irritable bowel syndrome, and/or pain associated with irritable bowel syndrome.

RET inhibitors, pharmaceutical compositions and uses thereof

A RET inhibitor, a pharmaceutical composition thereof and uses thereof including a compound having Formula (I) or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof. Furthermore, a pharmaceutical composition including the compound, and uses of the compound and pharmaceutical composition thereof in the manufacture of a medicament for treatment and prevention of RET-related diseases and conditions, including cancer, irritable bowel syndrome, and/or pain associated with irritable bowel syndrome.

A fused tricyclic compound and application thereof in medicine, especially as a medicament for the treatment and/or prevention of hepatitis B. Specifically, the present invention relates to a compound having Formula (I) or a stereoisomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, wherein each variable is as defined in the specification. The present invention also relates to the use of a compound having Formula (I) or a stereoisomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof as a medicament, especially as a medicament for the treatment and/or prevention of hepatitis B.

Fused tricyclic compounds and uses thereof in medicine

A fused tetracyclic compound and application thereof in medicine, especially as a medicament for the treatment and/or prevention of hepatitis B. A compound having Formula (I) or a stereoisomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, in medicine, especially as a medicament for the treatment and/or prevention of hepatitis B, wherein each variable is as defined in the specification. 

Fused tetracyclic compounds and uses thereof in medicine

An amine compound serving as a semicarbazide-sensitive amine oxidase (SSAO) and/or vascular adhesion protein-1 (VAP-1) inhibitor, a pharmaceutical composition, and an application thereof in medicines that can be used for treating inflammation and/or inflammation related diseases, diabetes and/or a disease related diabetes, psychiatric disorder, ischemic disease, vascular disease, fibrosis, or tissue transplant rejection.

Amine compound for inhibiting SSAO/VAP-1 and use thereof

A substituted pyrimidine piperazine compound and uses thereof, and a pharmaceutical composition containing the compound and uses thereof. Wherein the compound has Formula (I), or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof. The substituted pyrimidine piperazine compound and the pharmaceutical composition containing the compound can be used to inhibit 5-hydroxytryptamine reuptake and/or activate the 5-HTreceptors. Also, a method of preparing such compounds and pharmaceutical compositions, and uses thereof in the treatment of central nervous system dysfunction. 

Substituted pyrimidine piperazine compound and use thereof

A dihydropyrimidine compound and use as a medicament, especially application as a medicament used for treating and preventing hepatitis B, specifically, is a compound having Formula (I) or (Ia), or a stereoisomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, wherein the variables of the formulas are as defined in the specification; and also includes the use of the compound having Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof as a medicament, especially use as a medicament for treating and preventing hepatitis B. 

Dihydropyrimidine compounds and uses thereof in medicine

A class of fluorine-substituted indazole compounds and uses thereof having the general formula depicted below in which C1 is where is the bond through which C1 is attached to L, and C2 is where is the bond through which C2 is attached to indazole, and pharmaceutical compositions containing these compounds. The compounds and pharmaceutical compositions of the invention can be used as soluble guanylate cyclase simulators.

Fluorine-substituted indazole compounds and uses thereof

The invention provides a novel class of compounds as inhibitors of influenza virus replication, preparation methods thereof, pharmaceutical compositions containing these compounds, and uses of these compounds and pharmaceutical compositions thereof in the treatment of influenza.

Inhibitors of influenza virus replication, application methods and uses thereof

A pyrrolidineamide derivatives and uses thereof, specifically, the present invention relates to a novel pyrrolidineamide compound and a pharmaceutical composition containing this compound, which can be used as a MAO-B inhibitor. The present invention also relates to methods of preparing this compound and pharmaceutical composition, and their use in the manufacture of a medicament for treating a disease regulated by MAO-B comprising a neurodegenerative disease, especially Parkinson's disease.

Pyrrolidineamide derivatives and uses thereof

A salt of a substituted urea derivative of formula (I) and use thereof in the pharmaceutical field. Also, a pharmaceutical composition containing the salt or a combination thereof, and use of the salt or the pharmaceutical composition in the manufacture of a medicament for treating, remitting or preventing a disorder related to tyrosine kinase activity. 

Salt of substituted urea derivative and use thereof in medicine

Nitrogenous tricyclic compounds and uses thereof in medicine, in particular, a novel nitrogenous tricyclic compound used as an FXR active regulator and a stereoisomer, a geometrical isomer, a tautomer, a N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, and use of the compound in the manufacture of a drug for treating a disease and/or disorder regulated by FXR. A pharmaceutically acceptable composition containing the compound and a method of treating a disease and/or disorder mediated by FXR comprising administering the compound or pharmaceutical composition thereof.

Nitrogenous tricyclic compounds and uses thereof in medicine

A glucopyranosyl derivative is used as an inhibitor of sodium-dependent glucose transporters (SGLTs), particularly being used as an inhibitor of sodium-dependent glucose transporter-1 (SGLT1), and a pharmaceutically acceptable salt or stereoisomer thereof, further relating to a pharmaceutical composition containing the derivative. The compound and a pharmaceutical composition is used thereof in the preparation of a drug for treating diabetes and diabetes-related diseases.

Glucopyranosyl derivative and use thereof

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Dongguan, China

Yingjun Zhang